GDF5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GDF5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GDF5 at tissue level.

III. Associated gene sets

GO_0043932Biological processossification involved in bone remodeling
GO_0035136Biological processforelimb morphogenesis
GO_0002062Biological processchondrocyte differentiation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0097152Biological processmesenchymal cell apoptotic process
GO_0040014Biological processregulation of multicellular organism growth
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0007267Biological processcell-cell signaling
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0035137Biological processhindlimb morphogenesis
GO_0030509Biological processBMP signaling pathway
GO_0030326Biological processembryonic limb morphogenesis
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0009612Biological processresponse to mechanical stimulus
GO_0045666Biological processpositive regulation of neuron differentiation
GO_2001054Biological processnegative regulation of mesenchymal cell apoptotic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0060591Biological processchondroblast differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0042802Molecular functionidentical protein binding
GO_0008083Molecular functiongrowth factor activity
GO_0036122Molecular functionBMP binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameGDF5
Protein nameGDF5
GDF5 protein
Growth/differentiation factor 5
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
SynonymsCDMP1
BMP14
DescriptionFUNCTION: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes . .

AccessionsP43026
D3YRA6
F1T0J1
D3YR87
D3YR72
D3YR12
ENST00000374372.1
D3YR58
ENST00000374369.8
D3YRI8
D3YR76
Q2NKW7
D3YQT0
D3YQY5
D3YQZ2