FXYD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043269Biological processregulation of monoatomic ion transport
GO_2000649Biological processregulation of sodium ion transmembrane transporter activity
GO_0006813Biological processpotassium ion transport
GO_1902476Biological processchloride transmembrane transport
GO_0006814Biological processsodium ion transport
GO_0006821Biological processchloride transport
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0051117Molecular functionATPase binding
GO_0017080Molecular functionsodium channel regulator activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameFXYD3
Protein nameFXYD domain-containing ion transport regulator
FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)
SynonymsMAT8
PLML
DescriptionFUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell . Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 . Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes . .; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. .; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. .

AccessionsENST00000603181.5 [Q14802-1]
S4R445
ENST00000605550.5
Q14802
ENST00000603449.5 [Q14802-5]
ENST00000604404.6 [Q14802-1]
ENST00000604621.5 [Q14802-1]
A0A1S5UZ23
ENST00000603524.5
S4R3M2
ENST00000605677.1 [Q14802-4]
ENST00000346446.9 [Q14802-2]
ENST00000604804.5
ENST00000604255.5 [Q14802-3]
ENST00000435734.6 [Q14802-2]
ENST00000605552.5 [Q14802-5]
ENST00000344013.10 [Q14802-2]