FOXA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_2000543Biological processpositive regulation of gastrulation
GO_0001708Biological processcell fate specification
GO_0000432Biological processpositive regulation of transcription from RNA polymerase II promoter by glucose
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090009Biological processprimitive streak formation
GO_0008344Biological processadult locomotory behavior
GO_0061987Biological processnegative regulation of transcription from RNA polymerase II promoter by glucose
GO_0071542Biological processdopaminergic neuron differentiation
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0030193Biological processregulation of blood coagulation
GO_0040019Biological processpositive regulation of embryonic development
GO_0070741Biological processresponse to interleukin-6
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0030154Biological processcell differentiation
GO_0009653Biological processanatomical structure morphogenesis
GO_2000049Biological processpositive regulation of cell-cell adhesion mediated by cadherin
GO_0031018Biological processendocrine pancreas development
GO_0033132Biological processnegative regulation of glucokinase activity
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003676Molecular functionnucleic acid binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene nameFOXA2
Protein nameForkhead box A2
Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B)
SynonymsTCF3B
hCG_22162
HNF3B
DescriptionFUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. .

AccessionsENST00000419308.7 [Q9Y261-2]
Q9Y261
B0ZTD4
A0A2Z1D411
ENST00000377115.4 [Q9Y261-1]