FEN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	6 studies	26% ± 5%	Explore
natural killer cell	4 studies	29% ± 9%	Explore
CD4-positive, alpha-beta T cell	4 studies	31% ± 4%	Explore
B cell	3 studies	21% ± 3%	Explore
plasmablast	3 studies	46% ± 18%	Explore
hematopoietic precursor cell	3 studies	28% ± 12%	Explore
plasma cell	3 studies	28% ± 9%	Explore
epithelial cell	3 studies	22% ± 2%	Explore
erythroblast	3 studies	49% ± 23%	Explore
T cell	3 studies	23% ± 5%	Explore
erythrocyte	3 studies	32% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 8%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FEN1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	1362.59	1805 / 1809	100%	91.49	470 / 472
intestine	99%	732.85	961 / 966	99%	74.69	523 / 527
bladder	100%	425.33	21 / 21	99%	85.53	497 / 504
breast	99%	500.50	456 / 459	99%	67.83	1104 / 1118
esophagus	98%	766.36	1415 / 1445	100%	63.30	183 / 183
brain	98%	829.84	2596 / 2642	100%	50.65	702 / 705
stomach	97%	607.71	347 / 359	99%	65.49	282 / 286
prostate	96%	447.60	234 / 245	98%	30.45	490 / 502
uterus	91%	402.78	154 / 170	100%	126.68	459 / 459
lung	91%	549.31	525 / 578	98%	64.43	1135 / 1155
pancreas	92%	350.25	303 / 328	96%	38.06	170 / 178
liver	98%	522.70	221 / 226	89%	40.61	360 / 406
ovary	86%	373.86	155 / 180	98%	41.88	421 / 430
adrenal gland	100%	974.36	258 / 258	82%	29.27	189 / 230
thymus	90%	287.53	586 / 653	89%	33.38	538 / 605
kidney	91%	373.49	81 / 89	81%	19.79	727 / 901
lymph node	0%	0	0 / 0	100%	197.39	29 / 29
tonsil	0%	0	0 / 0	100%	133.07	45 / 45
ureter	0%	0	0 / 0	100%	75.18	1 / 1
muscle	100%	751.22	802 / 803	0%	0	0 / 0
spleen	100%	1276.99	240 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	98%	38.58	78 / 80
adipose	97%	488.37	1167 / 1204	0%	0	0 / 0
blood vessel	84%	302.84	1128 / 1335	0%	0	0 / 0
heart	81%	308.86	698 / 861	0%	0	0 / 0
peripheral blood	78%	1868.00	727 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006281	Biological process	DNA repair
GO_0090304	Biological process	nucleic acid metabolic process
GO_0009650	Biological process	UV protection
GO_0006287	Biological process	base-excision repair, gap-filling
GO_0006302	Biological process	double-strand break repair
GO_0006260	Biological process	DNA replication
GO_0045876	Biological process	positive regulation of sister chromatid cohesion
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0032201	Biological process	telomere maintenance via semi-conservative replication
GO_0007613	Biological process	memory
GO_0043137	Biological process	DNA replication, removal of RNA primer
GO_0005730	Cellular component	nucleolus
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0000781	Cellular component	chromosome, telomeric region
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0004527	Molecular function	exonuclease activity
GO_0008409	Molecular function	5'-3' exonuclease activity
GO_0004519	Molecular function	endonuclease activity
GO_0003690	Molecular function	double-stranded DNA binding
GO_0004523	Molecular function	RNA-DNA hybrid ribonuclease activity
GO_0017108	Molecular function	5'-flap endonuclease activity
GO_0000287	Molecular function	magnesium ion binding
GO_0030145	Molecular function	manganese ion binding
GO_0048256	Molecular function	flap endonuclease activity
GO_0008309	Molecular function	double-stranded DNA exodeoxyribonuclease activity
GO_0005515	Molecular function	protein binding
GO_0003684	Molecular function	damaged DNA binding

IV. Literature review

[source]

Gene name	FEN1
Protein name	Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) Flap structure-specific endonuclease 1 Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1)
Synonyms	RAD2 hCG_40848
Description	FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. . FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. .
Accessions	ENST00000305885.3 [P39748-1] P39748 Q6FHX6 F5H1Y3 ENST00000535723.1 ENST00000535307.1 I3L3E9

FEN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review