EYA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009653Biological processanatomical structure morphogenesis
GO_0007601Biological processvisual perception
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0048856Biological processanatomical structure development
GO_0030154Biological processcell differentiation
GO_0006338Biological processchromatin remodeling
GO_0010212Biological processresponse to ionizing radiation
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0140793Molecular functionhistone H2AXY142 phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameEYA3
Protein nameEyes absent homolog 3 (EC 3.1.3.48)
Eyes absent homolog (EC 3.1.3.48)
SynonymshCG_1640928
DescriptionFUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 . Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. .

AccessionsENST00000373871.8 [Q99504-1]
ENST00000540618.5 [Q99504-5]
Q0P685
ENST00000436342.6 [Q99504-4]
ENST00000373863.3 [Q99504-3]
ENST00000373864.5
Q99504
B1APR7