Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 26% ± 8% | |
microglial cell | 9 studies | 25% ± 9% | |
glutamatergic neuron | 8 studies | 40% ± 25% | |
oligodendrocyte | 8 studies | 29% ± 9% | |
GABAergic neuron | 7 studies | 36% ± 19% | |
astrocyte | 7 studies | 32% ± 13% | |
adipocyte | 6 studies | 20% ± 4% | |
dendritic cell | 6 studies | 17% ± 1% | |
fibroblast | 6 studies | 18% ± 2% | |
epithelial cell | 5 studies | 31% ± 12% | |
endothelial cell of lymphatic vessel | 5 studies | 21% ± 3% | |
macrophage | 5 studies | 30% ± 6% | |
type I pneumocyte | 5 studies | 20% ± 6% | |
type II pneumocyte | 5 studies | 22% ± 5% | |
interneuron | 5 studies | 38% ± 22% | |
cardiac muscle cell | 4 studies | 24% ± 2% | |
ciliated cell | 4 studies | 19% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 33% ± 7% | |
monocyte | 4 studies | 28% ± 4% | |
neuron | 3 studies | 32% ± 11% | |
myeloid cell | 3 studies | 24% ± 6% | |
club cell | 3 studies | 22% ± 5% | |
T cell | 3 studies | 17% ± 0% | |
alveolar macrophage | 3 studies | 29% ± 8% | |
pericyte | 3 studies | 17% ± 2% | |
lymphocyte | 3 studies | 23% ± 5% | |
mast cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1535.73 | 459 / 459 | 100% | 21.73 | 1118 / 1118 |
esophagus | 100% | 1745.40 | 1445 / 1445 | 100% | 21.93 | 183 / 183 |
intestine | 100% | 1618.61 | 966 / 966 | 100% | 16.45 | 527 / 527 |
prostate | 100% | 1841.48 | 245 / 245 | 100% | 20.28 | 502 / 502 |
stomach | 100% | 1163.25 | 359 / 359 | 100% | 16.38 | 286 / 286 |
uterus | 100% | 1777.10 | 170 / 170 | 100% | 21.23 | 459 / 459 |
lung | 100% | 1919.69 | 578 / 578 | 100% | 16.66 | 1154 / 1155 |
thymus | 100% | 2284.12 | 653 / 653 | 100% | 18.07 | 604 / 605 |
bladder | 100% | 1579.71 | 21 / 21 | 100% | 16.27 | 503 / 504 |
skin | 100% | 2136.73 | 1809 / 1809 | 100% | 27.03 | 471 / 472 |
ovary | 100% | 1581.71 | 180 / 180 | 100% | 17.18 | 429 / 430 |
brain | 100% | 1516.56 | 2631 / 2642 | 100% | 12.37 | 705 / 705 |
kidney | 100% | 2766.94 | 89 / 89 | 99% | 17.26 | 896 / 901 |
pancreas | 100% | 1102.42 | 327 / 328 | 99% | 14.65 | 177 / 178 |
adrenal gland | 100% | 1378.19 | 258 / 258 | 93% | 8.04 | 213 / 230 |
liver | 100% | 939.10 | 226 / 226 | 89% | 6.37 | 360 / 406 |
adipose | 100% | 1463.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1375.58 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.00 | 29 / 29 |
spleen | 100% | 2140.66 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 23.12 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.20 | 1 / 1 |
muscle | 100% | 1272.20 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 1205.00 | 854 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 22.31 | 79 / 80 |
peripheral blood | 97% | 1798.62 | 905 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009653 | Biological process | anatomical structure morphogenesis |
GO_0007601 | Biological process | visual perception |
GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
GO_0048856 | Biological process | anatomical structure development |
GO_0030154 | Biological process | cell differentiation |
GO_0006338 | Biological process | chromatin remodeling |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0006302 | Biological process | double-strand break repair |
GO_0005813 | Cellular component | centrosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
GO_0140793 | Molecular function | histone H2AXY142 phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | EYA3 |
Protein name | Eyes absent homolog 3 (EC 3.1.3.48) Eyes absent homolog (EC 3.1.3.48) |
Synonyms | hCG_1640928 |
Description | FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 . Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. . |
Accessions | ENST00000373871.8 [Q99504-1] ENST00000540618.5 [Q99504-5] Q0P685 ENST00000436342.6 [Q99504-4] ENST00000373863.3 [Q99504-3] ENST00000373864.5 Q99504 B1APR7 |