ERAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002474Biological processantigen processing and presentation of peptide antigen via MHC class I
GO_0001525Biological processangiogenesis
GO_0045444Biological processfat cell differentiation
GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0045766Biological processpositive regulation of angiogenesis
GO_0009617Biological processresponse to bacterium
GO_0008217Biological processregulation of blood pressure
GO_0045088Biological processregulation of innate immune response
GO_0002250Biological processadaptive immune response
GO_0006508Biological processproteolysis
GO_0043171Biological processpeptide catabolic process
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004175Molecular functionendopeptidase activity
GO_0070006Molecular functionmetalloaminopeptidase activity
GO_0042277Molecular functionpeptide binding
GO_0005151Molecular functioninterleukin-1, type II receptor binding
GO_0005138Molecular functioninterleukin-6 receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0004177Molecular functionaminopeptidase activity
GO_0008235Molecular functionmetalloexopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERAP1
Protein nameAminopeptidase (EC 3.4.11.-)
Endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform
Endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform
Endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform
Endoplasmic reticulum aminopeptidase 1
Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)
Endoplasmic reticulum aminopeptidase-1
SynonymsAPPILS
ARTS1
KIAA0525
UNQ584/PRO1154
DescriptionFUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. .

AccessionsA0A0A7E6P9
A0A0A7E7W9
ENST00000443439.7 [Q9NZ08-1]
A0A0A7E6D8
ENST00000296754.7 [Q9NZ08-2]
H0Y9X5
A0A1D5RMR7
ENST00000512852.1
ENST00000508227.5
A0A075BSP6
A0A0A7E7S5
A0A075BTL2
A0A411F1U7
A0A0A7E7X3
ENST00000507154.1
Q9NZ08
A0A0A7E6J5
A0A0A7E7W5
A0A0A7E6K0
A0A0A7E6P4
A0A075BV59
A0A0A7E6I2
A0A2I6QG18
A0A0A7E6P0
A0A0A7E6D4
A0A075BW43
A0A451F4J3
D6RAL9
A0A1S6KJG9
A0A0A7E7T3