Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 6 studies | 26% ± 7% | |
adipocyte | 5 studies | 27% ± 10% | |
oligodendrocyte | 5 studies | 20% ± 3% | |
astrocyte | 4 studies | 24% ± 5% | |
microglial cell | 4 studies | 21% ± 4% | |
endothelial cell | 4 studies | 21% ± 2% | |
cardiac muscle cell | 3 studies | 24% ± 6% | |
T cell | 3 studies | 18% ± 3% | |
mast cell | 3 studies | 19% ± 1% | |
GABAergic neuron | 3 studies | 44% ± 14% | |
glutamatergic neuron | 3 studies | 52% ± 19% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 1% | |
dendritic cell | 3 studies | 22% ± 7% | |
fibroblast | 3 studies | 20% ± 3% | |
macrophage | 3 studies | 22% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 16% ± 1% | |
plasmacytoid dendritic cell | 3 studies | 19% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 40% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2271.09 | 1444 / 1445 | 100% | 35.08 | 183 / 183 |
lung | 100% | 3682.97 | 578 / 578 | 100% | 29.84 | 1150 / 1155 |
stomach | 100% | 2441.30 | 359 / 359 | 99% | 34.29 | 284 / 286 |
intestine | 100% | 3920.82 | 966 / 966 | 99% | 33.74 | 522 / 527 |
breast | 100% | 3448.93 | 459 / 459 | 99% | 31.13 | 1103 / 1118 |
bladder | 100% | 2925.29 | 21 / 21 | 98% | 26.96 | 494 / 504 |
pancreas | 99% | 1806.23 | 325 / 328 | 98% | 27.37 | 175 / 178 |
uterus | 100% | 2965.89 | 170 / 170 | 97% | 26.47 | 445 / 459 |
thymus | 100% | 2237.83 | 652 / 653 | 97% | 23.33 | 586 / 605 |
kidney | 100% | 2187.04 | 89 / 89 | 96% | 33.64 | 867 / 901 |
liver | 100% | 1708.18 | 226 / 226 | 95% | 20.93 | 387 / 406 |
prostate | 100% | 2538.24 | 245 / 245 | 95% | 18.06 | 478 / 502 |
ovary | 100% | 2790.71 | 180 / 180 | 94% | 17.12 | 405 / 430 |
skin | 100% | 3240.60 | 1808 / 1809 | 94% | 25.46 | 443 / 472 |
brain | 89% | 877.55 | 2343 / 2642 | 99% | 20.18 | 696 / 705 |
adrenal gland | 100% | 2319.77 | 258 / 258 | 86% | 13.07 | 197 / 230 |
adipose | 100% | 4143.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2768.21 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3565.74 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2347.87 | 1334 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 43.21 | 44 / 45 |
heart | 97% | 1966.32 | 837 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 28.38 | 28 / 29 |
peripheral blood | 94% | 3292.32 | 873 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 73% | 8.69 | 58 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002474 | Biological process | antigen processing and presentation of peptide antigen via MHC class I |
GO_0001525 | Biological process | angiogenesis |
GO_0045444 | Biological process | fat cell differentiation |
GO_0019885 | Biological process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
GO_0045766 | Biological process | positive regulation of angiogenesis |
GO_0009617 | Biological process | response to bacterium |
GO_0008217 | Biological process | regulation of blood pressure |
GO_0045088 | Biological process | regulation of innate immune response |
GO_0002250 | Biological process | adaptive immune response |
GO_0006508 | Biological process | proteolysis |
GO_0043171 | Biological process | peptide catabolic process |
GO_0006509 | Biological process | membrane protein ectodomain proteolysis |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0004175 | Molecular function | endopeptidase activity |
GO_0070006 | Molecular function | metalloaminopeptidase activity |
GO_0042277 | Molecular function | peptide binding |
GO_0005151 | Molecular function | interleukin-1, type II receptor binding |
GO_0005138 | Molecular function | interleukin-6 receptor binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0004177 | Molecular function | aminopeptidase activity |
GO_0008235 | Molecular function | metalloexopeptidase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ERAP1 |
Protein name | Aminopeptidase (EC 3.4.11.-) Endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform Endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform Endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform Endoplasmic reticulum aminopeptidase 1 Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) Endoplasmic reticulum aminopeptidase-1 |
Synonyms | APPILS ARTS1 KIAA0525 UNQ584/PRO1154 |
Description | FUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. . |
Accessions | A0A0A7E6P9 A0A0A7E7W9 ENST00000443439.7 [Q9NZ08-1] A0A0A7E6D8 ENST00000296754.7 [Q9NZ08-2] H0Y9X5 A0A1D5RMR7 ENST00000512852.1 ENST00000508227.5 A0A075BSP6 A0A0A7E7S5 A0A075BTL2 A0A411F1U7 A0A0A7E7X3 ENST00000507154.1 Q9NZ08 A0A0A7E6J5 A0A0A7E7W5 A0A0A7E6K0 A0A0A7E6P4 A0A075BV59 A0A0A7E6I2 A0A2I6QG18 A0A0A7E6P0 A0A0A7E6D4 A0A075BW43 A0A451F4J3 D6RAL9 A0A1S6KJG9 A0A0A7E7T3 |