EPS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051016Biological processbarbed-end actin filament capping
GO_0070358Biological processactin polymerization-dependent cell motility
GO_0048149Biological processbehavioral response to ethanol
GO_0008344Biological processadult locomotory behavior
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0030832Biological processregulation of actin filament length
GO_1900029Biological processpositive regulation of ruffle assembly
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0036336Biological processdendritic cell migration
GO_0051017Biological processactin filament bundle assembly
GO_0010458Biological processexit from mitosis
GO_0051764Biological processactin crosslink formation
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0016601Biological processRac protein signal transduction
GO_0007266Biological processRho protein signal transduction
GO_0008360Biological processregulation of cell shape
GO_0032587Cellular componentruffle membrane
GO_0005903Cellular componentbrush border
GO_0098978Cellular componentglutamatergic synapse
GO_0032420Cellular componentstereocilium
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005938Cellular componentcell cortex
GO_0032426Cellular componentstereocilium tip
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0017146Cellular componentNMDA selective glutamate receptor complex
GO_0031982Cellular componentvesicle
GO_0031267Molecular functionsmall GTPase binding
GO_0003779Molecular functionactin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPS8
Protein nameEpidermal growth factor receptor pathway substrate 8
Epidermal growth factor receptor kinase substrate 8
Synonyms
DescriptionFUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. .

AccessionsF5H714
ENST00000645775.1 [Q12929-1]
ENST00000647224.1 [Q12929-1]
ENST00000544064.1
A0A2R8YE63
ENST00000543363.5
ENST00000642278.1 [Q12929-1]
ENST00000543612.5 [Q12929-1]
ENST00000642939.1
F5GYM8
F5H3Q6
ENST00000281172.10 [Q12929-1]
F5H1B5
ENST00000646918.1 [Q12929-1]
H0YFG1
ENST00000646828.1 [Q12929-1]
ENST00000536956.5
ENST00000542903.1 [Q12929-2]
Q12929
ENST00000536793.5
ENST00000540613.5 [Q12929-2]
A0A2R8Y4W2
ENST00000546261.1
ENST00000535752.5
ENST00000546311.5
ENST00000647087.1 [Q12929-1]
ENST00000644374.1 [Q12929-1]
F5H0R8
ENST00000646123.1
ENST00000543468.5
ENST00000543523.5 [Q12929-1]
F5H2B8