Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 41 studies | 55% ± 19% | |
fibroblast | 27 studies | 30% ± 16% | |
smooth muscle cell | 26 studies | 42% ± 16% | |
endothelial cell | 21 studies | 34% ± 19% | |
macrophage | 19 studies | 32% ± 18% | |
astrocyte | 17 studies | 37% ± 16% | |
ciliated cell | 14 studies | 36% ± 12% | |
oligodendrocyte precursor cell | 14 studies | 35% ± 13% | |
microglial cell | 14 studies | 45% ± 14% | |
epithelial cell | 12 studies | 32% ± 16% | |
type II pneumocyte | 11 studies | 46% ± 18% | |
adipocyte | 10 studies | 53% ± 14% | |
oligodendrocyte | 9 studies | 27% ± 11% | |
club cell | 8 studies | 34% ± 15% | |
connective tissue cell | 8 studies | 31% ± 12% | |
retinal rod cell | 8 studies | 52% ± 26% | |
myeloid cell | 8 studies | 31% ± 8% | |
basal cell | 8 studies | 27% ± 10% | |
renal alpha-intercalated cell | 7 studies | 66% ± 11% | |
retinal cone cell | 7 studies | 47% ± 21% | |
endothelial cell of artery | 7 studies | 21% ± 4% | |
mesothelial cell | 7 studies | 33% ± 17% | |
myofibroblast cell | 7 studies | 29% ± 16% | |
endothelial cell of vascular tree | 7 studies | 27% ± 14% | |
respiratory goblet cell | 6 studies | 38% ± 16% | |
GABAergic neuron | 6 studies | 28% ± 11% | |
epithelial cell of proximal tubule | 6 studies | 22% ± 7% | |
type I pneumocyte | 5 studies | 20% ± 5% | |
glutamatergic neuron | 5 studies | 36% ± 13% | |
abnormal cell | 5 studies | 26% ± 11% | |
ionocyte | 4 studies | 31% ± 7% | |
non-classical monocyte | 4 studies | 20% ± 4% | |
interneuron | 4 studies | 41% ± 20% | |
hepatic stellate cell | 3 studies | 61% ± 12% | |
conventional dendritic cell | 3 studies | 17% ± 1% | |
glial cell | 3 studies | 26% ± 11% | |
neuron | 3 studies | 35% ± 9% | |
dendritic cell | 3 studies | 29% ± 5% | |
mononuclear phagocyte | 3 studies | 30% ± 11% | |
secretory cell | 3 studies | 22% ± 6% | |
hepatocyte | 3 studies | 43% ± 13% | |
muscle cell | 3 studies | 61% ± 16% | |
enterocyte | 3 studies | 20% ± 4% | |
melanocyte | 3 studies | 43% ± 11% | |
vein endothelial cell | 3 studies | 46% ± 20% | |
brush cell | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 4952.11 | 89 / 89 | 99% | 66.51 | 888 / 901 |
intestine | 99% | 6008.95 | 959 / 966 | 98% | 47.06 | 519 / 527 |
lung | 99% | 4240.35 | 571 / 578 | 94% | 45.43 | 1086 / 1155 |
breast | 100% | 11026.07 | 459 / 459 | 90% | 24.58 | 1003 / 1118 |
bladder | 100% | 10149.71 | 21 / 21 | 88% | 32.95 | 445 / 504 |
stomach | 87% | 2700.03 | 313 / 359 | 98% | 47.14 | 280 / 286 |
skin | 90% | 8248.79 | 1627 / 1809 | 94% | 43.46 | 444 / 472 |
thymus | 100% | 6005.09 | 651 / 653 | 84% | 49.70 | 509 / 605 |
esophagus | 85% | 3301.16 | 1233 / 1445 | 84% | 37.32 | 154 / 183 |
uterus | 99% | 11045.14 | 169 / 170 | 62% | 15.99 | 286 / 459 |
prostate | 93% | 3606.95 | 228 / 245 | 65% | 8.89 | 327 / 502 |
brain | 62% | 1501.83 | 1637 / 2642 | 92% | 18.32 | 652 / 705 |
liver | 70% | 1728.96 | 159 / 226 | 76% | 16.97 | 307 / 406 |
ovary | 100% | 7732.73 | 180 / 180 | 41% | 5.83 | 177 / 430 |
pancreas | 33% | 714.84 | 107 / 328 | 95% | 42.09 | 169 / 178 |
adrenal gland | 64% | 1614.03 | 165 / 258 | 36% | 5.66 | 83 / 230 |
adipose | 100% | 16065.02 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 16374.56 | 1335 / 1335 | 0% | 0 | 0 / 0 |
heart | 90% | 3351.14 | 771 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 24.83 | 67 / 80 |
muscle | 71% | 1927.67 | 574 / 803 | 0% | 0 | 0 / 0 |
spleen | 68% | 2404.00 | 164 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 51% | 8.78 | 23 / 45 |
lymph node | 0% | 0 | 0 / 0 | 10% | 1.59 | 3 / 29 |
peripheral blood | 6% | 251.85 | 60 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051016 | Biological process | barbed-end actin filament capping |
GO_0070358 | Biological process | actin polymerization-dependent cell motility |
GO_0048149 | Biological process | behavioral response to ethanol |
GO_0008344 | Biological process | adult locomotory behavior |
GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
GO_0030832 | Biological process | regulation of actin filament length |
GO_1900029 | Biological process | positive regulation of ruffle assembly |
GO_0099072 | Biological process | regulation of postsynaptic membrane neurotransmitter receptor levels |
GO_0036336 | Biological process | dendritic cell migration |
GO_0051017 | Biological process | actin filament bundle assembly |
GO_0010458 | Biological process | exit from mitosis |
GO_0051764 | Biological process | actin crosslink formation |
GO_0035023 | Biological process | regulation of Rho protein signal transduction |
GO_0016601 | Biological process | Rac protein signal transduction |
GO_0007266 | Biological process | Rho protein signal transduction |
GO_0008360 | Biological process | regulation of cell shape |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005903 | Cellular component | brush border |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0032420 | Cellular component | stereocilium |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005938 | Cellular component | cell cortex |
GO_0032426 | Cellular component | stereocilium tip |
GO_0014069 | Cellular component | postsynaptic density |
GO_0030426 | Cellular component | growth cone |
GO_0017146 | Cellular component | NMDA selective glutamate receptor complex |
GO_0031982 | Cellular component | vesicle |
GO_0031267 | Molecular function | small GTPase binding |
GO_0003779 | Molecular function | actin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | EPS8 |
Protein name | Epidermal growth factor receptor pathway substrate 8 Epidermal growth factor receptor kinase substrate 8 |
Synonyms | |
Description | FUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. . |
Accessions | F5H714 ENST00000645775.1 [Q12929-1] ENST00000647224.1 [Q12929-1] ENST00000544064.1 A0A2R8YE63 ENST00000543363.5 ENST00000642278.1 [Q12929-1] ENST00000543612.5 [Q12929-1] ENST00000642939.1 F5GYM8 F5H3Q6 ENST00000281172.10 [Q12929-1] F5H1B5 ENST00000646918.1 [Q12929-1] H0YFG1 ENST00000646828.1 [Q12929-1] ENST00000536956.5 ENST00000542903.1 [Q12929-2] Q12929 ENST00000536793.5 ENST00000540613.5 [Q12929-2] A0A2R8Y4W2 ENST00000546261.1 ENST00000535752.5 ENST00000546311.5 ENST00000647087.1 [Q12929-1] ENST00000644374.1 [Q12929-1] F5H0R8 ENST00000646123.1 ENST00000543468.5 ENST00000543523.5 [Q12929-1] F5H2B8 |