EPHB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	15 studies	45% ± 19%	Explore
glutamatergic neuron	12 studies	42% ± 23%	Explore
plasmacytoid dendritic cell	12 studies	25% ± 7%	Explore
oligodendrocyte precursor cell	11 studies	34% ± 9%	Explore
GABAergic neuron	9 studies	38% ± 20%	Explore
interneuron	6 studies	46% ± 16%	Explore
granule cell	4 studies	51% ± 17%	Explore
endothelial cell	3 studies	50% ± 19%	Explore
GABAergic interneuron	3 studies	39% ± 28%	Explore
neuron	3 studies	42% ± 20%	Explore
cardiac muscle cell	3 studies	19% ± 5%	Explore
GABAergic amacrine cell	3 studies	24% ± 3%	Explore
Mueller cell	3 studies	37% ± 7%	Explore
glycinergic amacrine cell	3 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	3 studies	18% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	36% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	1836.36	2520 / 2642	97%	45.27	684 / 705
thymus	91%	637.01	596 / 653	60%	3.60	364 / 605
skin	83%	840.08	1494 / 1809	21%	1.51	99 / 472
muscle	90%	509.54	724 / 803	0%	0	0 / 0
intestine	52%	402.12	506 / 966	32%	2.32	169 / 527
breast	56%	359.16	255 / 459	24%	1.69	266 / 1118
uterus	56%	332.17	96 / 170	18%	2.33	83 / 459
adrenal gland	38%	119.67	97 / 258	28%	2.78	64 / 230
peripheral blood	65%	571.37	603 / 929	0%	0	0 / 0
stomach	23%	127.17	81 / 359	40%	2.80	114 / 286
bladder	43%	316.19	9 / 21	16%	1.24	80 / 504
prostate	49%	253.36	119 / 245	10%	0.37	49 / 502
kidney	26%	70.62	23 / 89	30%	1.86	266 / 901
spleen	50%	129.75	120 / 241	0%	0	0 / 0
esophagus	17%	108.40	244 / 1445	33%	2.40	60 / 183
ovary	12%	60.27	21 / 180	36%	1.76	154 / 430
liver	41%	146.79	92 / 226	3%	0.09	11 / 406
blood vessel	39%	173.22	522 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	7.34	10 / 29
lung	2%	4.38	12 / 578	30%	2.65	351 / 1155
tonsil	0%	0	0 / 0	29%	2.44	13 / 45
eye	0%	0	0 / 0	20%	1.15	16 / 80
adipose	17%	46.40	204 / 1204	0%	0	0 / 0
pancreas	0%	0	0 / 328	11%	0.49	20 / 178
heart	3%	7.66	29 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030010	Biological process	establishment of cell polarity
GO_0001525	Biological process	angiogenesis
GO_0031589	Biological process	cell-substrate adhesion
GO_0046328	Biological process	regulation of JNK cascade
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0001771	Biological process	immunological synapse formation
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_1902723	Biological process	negative regulation of skeletal muscle satellite cell proliferation
GO_0048593	Biological process	camera-type eye morphogenesis
GO_0061351	Biological process	neural precursor cell proliferation
GO_0021631	Biological process	optic nerve morphogenesis
GO_0021934	Biological process	hindbrain tangential cell migration
GO_0021952	Biological process	central nervous system projection neuron axonogenesis
GO_0022008	Biological process	neurogenesis
GO_0060996	Biological process	dendritic spine development
GO_0050965	Biological process	detection of temperature stimulus involved in sensory perception of pain
GO_0014719	Biological process	skeletal muscle satellite cell activation
GO_1902725	Biological process	negative regulation of satellite cell differentiation
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0031290	Biological process	retinal ganglion cell axon guidance
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0060326	Biological process	cell chemotaxis
GO_0007411	Biological process	axon guidance
GO_0060997	Biological process	dendritic spine morphogenesis
GO_0098978	Cellular component	glutamatergic synapse
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0031901	Cellular component	early endosome membrane
GO_0032433	Cellular component	filopodium tip
GO_0070062	Cellular component	extracellular exosome
GO_0030425	Cellular component	dendrite
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0030424	Cellular component	axon
GO_0044877	Molecular function	protein-containing complex binding
GO_0008046	Molecular function	axon guidance receptor activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EPHB1
Protein name	Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) EPH receptor B1 receptor protein-tyrosine kinase (EC 2.7.10.1)
Synonyms	ELK HEK6 EPHT2 NET
Description	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). .
Accessions	F8WDG5 ENST00000398015.8 [P54762-1] ENST00000474732.1 ENST00000497173.5 C9J6S4 ENST00000647596.1 C9K090 ENST00000482618.5 C9J466 A0A3B3IRY8 P54762 ENST00000473867.5 ENST00000493838.1 [P54762-5]

EPHB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review