ELF4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ELF4 at tissue level.

III. Associated gene sets

GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0001866Biological processNK T cell proliferation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0001787Biological processnatural killer cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameELF4
Protein nameE74 like ETS transcription factor 4
ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor)
SynonymsELFR
MEF
DescriptionFUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells . Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN . Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 . Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) . .

AccessionsQ99607
B1AL80
ENST00000335997.11
ENST00000434609.1
ENST00000308167.10