EIF2AK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0001525Biological processangiogenesis
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0042149Biological processcellular response to glucose starvation
GO_1990737Biological processresponse to manganese-induced endoplasmic reticulum stress
GO_0019722Biological processcalcium-mediated signaling
GO_0031642Biological processnegative regulation of myelination
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0032055Biological processnegative regulation of translation in response to stress
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007029Biological processendoplasmic reticulum organization
GO_0010628Biological processpositive regulation of gene expression
GO_0006983Biological processER overload response
GO_1902235Biological processregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0036492Biological processeiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO_0036499Biological processPERK-mediated unfolded protein response
GO_0002063Biological processchondrocyte development
GO_0070417Biological processcellular response to cold
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0060734Biological processregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO_0010998Biological processregulation of translational initiation by eIF2 alpha phosphorylation
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0030282Biological processbone mineralization
GO_0045947Biological processnegative regulation of translational initiation
GO_0034198Biological processcellular response to amino acid starvation
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0001501Biological processskeletal system development
GO_0031018Biological processendocrine pancreas development
GO_0001503Biological processossification
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0032057Biological processnegative regulation of translational initiation in response to stress
GO_0017148Biological processnegative regulation of translation
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004694Molecular functioneukaryotic translation initiation factor 2alpha kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0051879Molecular functionHsp90 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF2AK3
Protein namePRKR-like endoplasmic reticulum kinase
Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)
Eukaryotic translation initiation factor 2 alpha kinase 3
Truncated eukaryotic translation initiation factor 2 alpha kinase 3 (EC 2.7.11.1)
SynonymsPEK
PERK
DescriptionFUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming . Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). .

AccessionsQ9NZJ5
ENST00000652099.1
ENST00000682103.1
ENST00000303236.9
A0A804HJ50
ENST00000682603.1
A0A804HI66
ENST00000652423.1
A0A804HL08
A0A804HIT4
A0A6C0SHM7
ENST00000682844.1
A0A6C0SHA8
A0A804HLC2
ENST00000684455.1
A0A494C186
ENST00000684642.1
ENST00000682892.1
A0A804HJV6
A0A494BZR8