EDEM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904154Biological processpositive regulation of retrograde protein transport, ER to cytosol
GO_0005975Biological processcarbohydrate metabolic process
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006986Biological processresponse to unfolded protein
GO_0045047Biological processprotein targeting to ER
GO_1904382Biological processmannose trimming involved in glycoprotein ERAD pathway
GO_0006058Biological processmannoprotein catabolic process
GO_1904380Biological processendoplasmic reticulum mannose trimming
GO_0036503Biological processERAD pathway
GO_0005783Cellular componentendoplasmic reticulum
GO_0016235Cellular componentaggresome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0004571Molecular functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO_0051787Molecular functionmisfolded protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEDEM1
Protein nameER degradation-enhancing alpha-mannosidase-like protein 1
alpha-1,2-Mannosidase (EC 3.2.1.-)
ER degradation enhancing alpha-mannosidase like protein 1
SynonymsEDEM
KIAA0212
DescriptionFUNCTION: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. .

AccessionsQ92611
ENST00000256497.9 [Q92611-1]
ENST00000445686.1 [Q92611-2]
ENST00000443790.1
F8WER9
F8WE67
ENST00000434243.5