Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 7 studies | 22% ± 6% | |
| plasma cell | 7 studies | 32% ± 12% | |
| plasmablast | 6 studies | 28% ± 14% | |
| B cell | 5 studies | 19% ± 2% | |
| conventional dendritic cell | 5 studies | 20% ± 3% | |
| type II pneumocyte | 5 studies | 22% ± 8% | |
| plasmacytoid dendritic cell | 5 studies | 23% ± 11% | |
| macrophage | 4 studies | 21% ± 6% | |
| classical monocyte | 3 studies | 20% ± 3% | |
| myeloid cell | 3 studies | 24% ± 2% | |
| epithelial cell | 3 studies | 26% ± 1% | |
| pro-B cell | 3 studies | 30% ± 4% | |
| hepatocyte | 3 studies | 29% ± 17% | |
| GABAergic neuron | 3 studies | 22% ± 2% | |
| glutamatergic neuron | 3 studies | 28% ± 6% | |
| dendritic cell | 3 studies | 35% ± 11% | |
| goblet cell | 3 studies | 29% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 3400.56 | 459 / 459 | 100% | 49.05 | 1113 / 1118 |
| lung | 100% | 6906.96 | 578 / 578 | 99% | 51.43 | 1149 / 1155 |
| esophagus | 100% | 2946.94 | 1445 / 1445 | 99% | 34.45 | 182 / 183 |
| bladder | 100% | 2978.95 | 21 / 21 | 99% | 40.63 | 500 / 504 |
| thymus | 100% | 3313.09 | 652 / 653 | 99% | 54.92 | 601 / 605 |
| prostate | 100% | 3165.97 | 245 / 245 | 99% | 35.05 | 497 / 502 |
| stomach | 100% | 2933.66 | 359 / 359 | 99% | 26.41 | 283 / 286 |
| pancreas | 100% | 4152.42 | 328 / 328 | 99% | 34.27 | 176 / 178 |
| intestine | 100% | 3421.25 | 966 / 966 | 98% | 27.91 | 518 / 527 |
| liver | 100% | 9332.30 | 226 / 226 | 98% | 29.09 | 399 / 406 |
| kidney | 100% | 2290.62 | 89 / 89 | 97% | 28.11 | 877 / 901 |
| uterus | 100% | 3672.78 | 170 / 170 | 97% | 31.56 | 446 / 459 |
| skin | 100% | 5389.95 | 1809 / 1809 | 97% | 47.97 | 457 / 472 |
| adrenal gland | 100% | 3251.88 | 258 / 258 | 89% | 18.60 | 205 / 230 |
| ovary | 100% | 3583.64 | 180 / 180 | 85% | 13.42 | 364 / 430 |
| brain | 90% | 1265.51 | 2381 / 2642 | 94% | 12.90 | 663 / 705 |
| adipose | 100% | 3206.13 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 64.65 | 29 / 29 |
| spleen | 100% | 6923.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 39.29 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.61 | 1 / 1 |
| blood vessel | 100% | 2787.75 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 7672.44 | 900 / 929 | 0% | 0 | 0 / 0 |
| heart | 93% | 1331.73 | 802 / 861 | 0% | 0 | 0 / 0 |
| muscle | 76% | 905.82 | 609 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 60% | 8.60 | 48 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1904154 | Biological process | positive regulation of retrograde protein transport, ER to cytosol |
| GO_0005975 | Biological process | carbohydrate metabolic process |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0006986 | Biological process | response to unfolded protein |
| GO_0045047 | Biological process | protein targeting to ER |
| GO_1904382 | Biological process | mannose trimming involved in glycoprotein ERAD pathway |
| GO_0006058 | Biological process | mannoprotein catabolic process |
| GO_1904380 | Biological process | endoplasmic reticulum mannose trimming |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0016235 | Cellular component | aggresome |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0044322 | Cellular component | endoplasmic reticulum quality control compartment |
| GO_0004571 | Molecular function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| GO_0051787 | Molecular function | misfolded protein binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EDEM1 |
| Protein name | ER degradation-enhancing alpha-mannosidase-like protein 1 alpha-1,2-Mannosidase (EC 3.2.1.-) ER degradation enhancing alpha-mannosidase like protein 1 |
| Synonyms | EDEM KIAA0212 |
| Description | FUNCTION: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. . |
| Accessions | Q92611 ENST00000256497.9 [Q92611-1] ENST00000445686.1 [Q92611-2] ENST00000443790.1 F8WER9 F8WE67 ENST00000434243.5 |