EBF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameEBF1
Protein nameEBF transcription factor 1
Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)
SynonymsEBF
COE1
DescriptionFUNCTION: Key pioneer transcription factor of B-cell specification and commitment . Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). .; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells . In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency . .

AccessionsENST00000313708.11 [Q9UH73-1]
ENST00000380654.8 [Q9UH73-2]
ENST00000517373.1
Q9UH73
E5RFQ1