I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 26% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 26% ± 7% |
Insufficient scRNA-seq data for expression of DVL2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2896.26 | 1445 / 1445 | 100% | 27.96 | 183 / 183 |
| ovary | 100% | 4617.31 | 180 / 180 | 100% | 25.89 | 430 / 430 |
| prostate | 100% | 3822.71 | 245 / 245 | 100% | 27.33 | 502 / 502 |
| skin | 100% | 3346.72 | 1809 / 1809 | 100% | 43.94 | 471 / 472 |
| uterus | 100% | 4384.11 | 170 / 170 | 100% | 28.33 | 457 / 459 |
| thymus | 100% | 3134.61 | 653 / 653 | 100% | 29.48 | 602 / 605 |
| lung | 100% | 2171.34 | 577 / 578 | 100% | 25.42 | 1151 / 1155 |
| intestine | 100% | 2710.22 | 966 / 966 | 99% | 18.83 | 524 / 527 |
| breast | 100% | 2676.69 | 459 / 459 | 99% | 21.35 | 1111 / 1118 |
| stomach | 100% | 1648.59 | 359 / 359 | 99% | 18.92 | 284 / 286 |
| bladder | 100% | 3069.57 | 21 / 21 | 99% | 22.91 | 498 / 504 |
| brain | 99% | 1662.85 | 2607 / 2642 | 100% | 33.91 | 705 / 705 |
| pancreas | 99% | 1016.47 | 325 / 328 | 99% | 19.37 | 176 / 178 |
| kidney | 100% | 2180.84 | 89 / 89 | 98% | 19.37 | 881 / 901 |
| adrenal gland | 100% | 2900.26 | 258 / 258 | 97% | 16.05 | 223 / 230 |
| liver | 96% | 805.41 | 218 / 226 | 86% | 11.61 | 348 / 406 |
| adipose | 100% | 2242.28 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2626.04 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 22.94 | 29 / 29 |
| spleen | 100% | 2318.26 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 30.40 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.99 | 1 / 1 |
| muscle | 99% | 1252.63 | 794 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 33.06 | 79 / 80 |
| heart | 97% | 1209.84 | 839 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 83% | 1139.39 | 768 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0007507 | Biological process | heart development |
| GO_0001947 | Biological process | heart looping |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0090179 | Biological process | planar cell polarity pathway involved in neural tube closure |
| GO_0150012 | Biological process | positive regulation of neuron projection arborization |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0022007 | Biological process | convergent extension involved in neural plate elongation |
| GO_0007379 | Biological process | segment specification |
| GO_0001843 | Biological process | neural tube closure |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
| GO_0008104 | Biological process | protein localization |
| GO_0035567 | Biological process | non-canonical Wnt signaling pathway |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0016328 | Cellular component | lateral plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0016235 | Cellular component | aggresome |
| GO_0005634 | Cellular component | nucleus |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005109 | Molecular function | frizzled binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DVL2 |
| Protein name | Dishevelled segment polarity protein 2 Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) |
| Synonyms | |
| Description | FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. . |
| Accessions | ENST00000575458.5 ENST00000005340.10 O14641 I3L2N2 I3L2W9 I3L0M7 ENST00000575756.5 ENST00000575086.1 I3L0Z8 ENST00000574143.1 |
