DUSP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043409Biological processnegative regulation of MAPK cascade
GO_0001706Biological processendoderm formation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0016311Biological processdephosphorylation
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017017Molecular functionMAP kinase tyrosine/serine/threonine phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_1990439Molecular functionMAP kinase serine/threonine phosphatase activity
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0008330Molecular functionprotein tyrosine/threonine phosphatase activity
GO_0033550Molecular functionMAP kinase tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDUSP4
Protein nameDual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
SynonymsVH2
MKP2
DescriptionFUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. .

AccessionsENST00000240101.2 [Q13115-2]
Q13115
ENST00000240100.7 [Q13115-1]