DISC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	33% ± 15%	Explore
microglial cell	14 studies	61% ± 21%	Explore
oligodendrocyte precursor cell	13 studies	58% ± 21%	Explore
macrophage	12 studies	46% ± 24%	Explore
oligodendrocyte	9 studies	28% ± 16%	Explore
myeloid cell	7 studies	44% ± 18%	Explore
GABAergic neuron	6 studies	26% ± 10%	Explore
dendritic cell	6 studies	31% ± 10%	Explore
cardiac muscle cell	5 studies	47% ± 10%	Explore
retinal rod cell	5 studies	71% ± 29%	Explore
fibroblast	5 studies	20% ± 5%	Explore
pericyte	4 studies	27% ± 12%	Explore
mast cell	4 studies	26% ± 9%	Explore
astrocyte	4 studies	41% ± 16%	Explore
retinal cone cell	4 studies	25% ± 5%	Explore
T cell	4 studies	18% ± 3%	Explore
monocyte	4 studies	38% ± 7%	Explore
CD4-positive, alpha-beta T cell	3 studies	28% ± 7%	Explore
mononuclear phagocyte	3 studies	30% ± 10%	Explore
endothelial cell of vascular tree	3 studies	27% ± 14%	Explore
alveolar macrophage	3 studies	32% ± 6%	Explore
endothelial cell of lymphatic vessel	3 studies	21% ± 4%	Explore
lymphocyte	3 studies	30% ± 1%	Explore
glutamatergic neuron	3 studies	28% ± 4%	Explore
neuron	3 studies	41% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	25% ± 12%	Explore
heart	4 studies	31% ± 8%	Explore
eye	3 studies	55% ± 16%	Explore
lung	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	615.79	2612 / 2642	99%	6.95	699 / 705
skin	99%	354.71	1782 / 1809	97%	7.12	460 / 472
thymus	100%	524.97	652 / 653	81%	1.62	493 / 605
kidney	98%	332.11	87 / 89	79%	2.53	708 / 901
prostate	99%	446.04	242 / 245	77%	1.74	386 / 502
breast	100%	632.22	459 / 459	72%	1.52	806 / 1118
lung	100%	601.80	577 / 578	71%	1.68	819 / 1155
esophagus	99%	430.05	1431 / 1445	65%	1.48	119 / 183
ovary	100%	1011.32	180 / 180	63%	1.27	273 / 430
adrenal gland	100%	454.90	258 / 258	49%	0.91	112 / 230
intestine	100%	508.86	964 / 966	45%	0.84	239 / 527
uterus	99%	394.42	169 / 170	45%	1.20	205 / 459
stomach	95%	274.18	342 / 359	45%	0.84	128 / 286
pancreas	51%	99.23	167 / 328	83%	1.68	147 / 178
bladder	95%	394.71	20 / 21	34%	0.80	171 / 504
adipose	100%	835.15	1204 / 1204	0%	0	0 / 0
spleen	100%	881.99	241 / 241	0%	0	0 / 0
heart	100%	701.27	859 / 861	0%	0	0 / 0
blood vessel	90%	324.17	1207 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	90%	4.05	72 / 80
muscle	85%	268.91	684 / 803	0%	0	0 / 0
peripheral blood	85%	883.03	790 / 929	0%	0	0 / 0
liver	43%	74.38	98 / 226	17%	0.41	68 / 406
tonsil	0%	0	0 / 0	53%	1.27	24 / 45
lymph node	0%	0	0 / 0	48%	0.91	14 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_1905515	Biological process	non-motile cilium assembly
GO_0060271	Biological process	cilium assembly
GO_0021846	Biological process	cell proliferation in forebrain
GO_0045773	Biological process	positive regulation of axon extension
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0051602	Biological process	response to electrical stimulus
GO_0031929	Biological process	TOR signaling
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0071539	Biological process	protein localization to centrosome
GO_0090128	Biological process	regulation of synapse maturation
GO_0001764	Biological process	neuron migration
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0070050	Biological process	neuron cellular homeostasis
GO_0060998	Biological process	regulation of dendritic spine development
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_2000060	Biological process	positive regulation of ubiquitin-dependent protein catabolic process
GO_0051560	Biological process	mitochondrial calcium ion homeostasis
GO_0050965	Biological process	detection of temperature stimulus involved in sensory perception of pain
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0021852	Biological process	pyramidal neuron migration to cerebral cortex
GO_0032091	Biological process	negative regulation of protein binding
GO_0099175	Biological process	regulation of postsynapse organization
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0005874	Cellular component	microtubule
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005813	Cellular component	centrosome
GO_0005871	Cellular component	kinesin complex
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_0098982	Cellular component	GABA-ergic synapse
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0014069	Cellular component	postsynaptic density
GO_0097546	Cellular component	ciliary base
GO_0044297	Cellular component	cell body
GO_0090724	Cellular component	central region of growth cone
GO_0036064	Cellular component	ciliary basal body
GO_0030286	Cellular component	dynein complex
GO_0060090	Molecular function	molecular adaptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0019894	Molecular function	kinesin binding

IV. Literature review

[source]

Gene name	DISC1
Protein name	DISC1 scaffold protein (Disrupted in schizophrenia 1 isoform 28) (Disrupted in schizophrenia 1 isoform 39) (Disrupted in schizophrenia 1 isoform 4) Disrupted in schizophrenia 1 isoform A Disrupted in schizophrenia 1 isoform 45 Disrupted in schizophrenia 1 isoform 21 Disrupted in schizophrenia 1 isoform 40 Disrupted in schizophrenia 1 isoform 43 Disrupted in schizophrenia 1 isoform 6 Disrupted in schizophrenia 1 isoform 37 Disrupted in schizophrenia 1 isoform 41 Disrupted in schizophrenia 1 isoform 44 DISC1 scaffold protein Disrupted in schizophrenia 1 isoform 46 Disrupted in schizophrenia 1 DISC1 scaffold protein (Disrupted in schizophrenia 1 isoform 12) Disrupted in schizophrenia 1 protein DISC1 scaffold protein (Disrupted in schizophrenia 1 isoform 24) DISC1 scaffold protein (Disrupted in schizophrenia 1 isoform 23) (Disrupted in schizophrenia 1 isoform 36) Disrupted in schizophrenia 1 isoform 10 Disrupted in schizophrenia 1 isoform 17 (Disrupted in schizophrenia 1 isoform 32) Disrupted in schizophrenia 1 isoform 8 DISC1 scaffold protein (Disrupted in schizophrenia 1 isoform 14) (Disrupted in schizophrenia 1 isoform 18) (Disrupted in schizophrenia 1 isoform 31) (Disrupted in schizophrenia 1 isoform 5) Disrupted in schizophrenia 1 isoform 16 Disrupted in schizophrenia 1 isoform 25
Synonyms	KIAA0457
Description	FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis . Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance . Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development . Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation . .
Accessions	ENST00000366633.7 [Q9NRI5-5] ENST00000422590.6 A7E2W8 C4P093 C4P0B0 ENST00000602700.5 [Q9NRI5-10] ENST00000602822.5 [Q9NRI5-10] Q9NRI5 ENST00000628350.2 [Q9NRI5-7] C4P094 ENST00000602873.5 [Q9NRI5-11] ENST00000295051.11 C4P0C8 ENST00000366632.6 C4P0A5 ENST00000622252.4 C4P0B2 ENST00000317586.8 [Q9NRI5-4] ENST00000535983.5 [Q9NRI5-8] C4P0B1 C4P0A4 ENST00000366637.8 [Q9NRI5-2] C4P098 ENST00000439617.8 [Q9NRI5-1] ENST00000366636.8 [Q9NRI5-3] C4P0A9 ENST00000537876.5 C4P0A0 ENST00000602281.5 [Q9NRI5-9] ENST00000539444.5 [Q9NRI5-6] ENST00000602713.5 [Q9NRI5-10] C4P092 C4P096 C4P0C7 X5DQV8 C4P0D1 H0Y7U2 C4P0D0 C4P0D3 ENST00000535944.5 C4P0C4 C4P0D2

DISC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review