DIS3L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0051301Biological processcell division
GO_0051306Biological processmitotic sister chromatid separation
GO_0000278Biological processmitotic cell cycle
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0019827Biological processstem cell population maintenance
GO_0006402Biological processmRNA catabolic process
GO_0010587Biological processmiRNA catabolic process
GO_1990074Biological processpolyuridylation-dependent mRNA catabolic process
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0008266Molecular functionpoly(U) RNA binding
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameDIS3L2
Protein nameDIS3 like 3'-5' exoribonuclease 2
DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)
SynonymsFAM6A
DescriptionFUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. .

AccessionsENST00000417808.1
Q8IYB7
ENST00000273009.10 [Q8IYB7-3]
ENST00000325385.12 [Q8IYB7-1]
H7C302
ENST00000418143.1
ENST00000445090.5 [Q8IYB7-4]
ENST00000434477.5
ENST00000409401.7 [Q8IYB7-4]
ENST00000441279.5
H7C1Q8
C9JGP4
ENST00000433430.5 [Q8IYB7-5]
ENST00000390005.9 [Q8IYB7-2]
H7C036