Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 31% ± 12% | |
| oligodendrocyte | 13 studies | 39% ± 16% | |
| astrocyte | 13 studies | 36% ± 19% | |
| microglial cell | 11 studies | 29% ± 12% | |
| glutamatergic neuron | 10 studies | 43% ± 27% | |
| oligodendrocyte precursor cell | 9 studies | 31% ± 13% | |
| adipocyte | 9 studies | 25% ± 7% | |
| GABAergic neuron | 8 studies | 46% ± 26% | |
| fibroblast | 7 studies | 30% ± 11% | |
| ciliated cell | 7 studies | 36% ± 17% | |
| neuron | 6 studies | 38% ± 21% | |
| interneuron | 6 studies | 46% ± 24% | |
| macrophage | 6 studies | 34% ± 6% | |
| epithelial cell | 6 studies | 31% ± 16% | |
| endothelial cell of lymphatic vessel | 6 studies | 33% ± 10% | |
| smooth muscle cell | 5 studies | 21% ± 4% | |
| type I pneumocyte | 5 studies | 28% ± 7% | |
| type II pneumocyte | 5 studies | 29% ± 8% | |
| granule cell | 4 studies | 25% ± 8% | |
| cardiac muscle cell | 4 studies | 19% ± 1% | |
| amacrine cell | 4 studies | 20% ± 4% | |
| retina horizontal cell | 4 studies | 23% ± 6% | |
| retinal cone cell | 4 studies | 28% ± 9% | |
| retinal rod cell | 4 studies | 29% ± 4% | |
| dendritic cell | 4 studies | 17% ± 1% | |
| club cell | 4 studies | 30% ± 12% | |
| pericyte | 4 studies | 24% ± 7% | |
| basal cell | 4 studies | 37% ± 18% | |
| GABAergic interneuron | 3 studies | 30% ± 4% | |
| Mueller cell | 3 studies | 22% ± 6% | |
| glycinergic amacrine cell | 3 studies | 18% ± 2% | |
| myeloid cell | 3 studies | 21% ± 2% | |
| hepatocyte | 3 studies | 38% ± 16% | |
| ependymal cell | 3 studies | 46% ± 13% | |
| T cell | 3 studies | 22% ± 0% | |
| alveolar macrophage | 3 studies | 25% ± 7% | |
| monocyte | 3 studies | 25% ± 2% | |
| lymphocyte | 3 studies | 29% ± 6% | |
| mucus secreting cell | 3 studies | 25% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1810.92 | 1445 / 1445 | 100% | 7.91 | 183 / 183 |
| prostate | 100% | 2201.70 | 245 / 245 | 100% | 8.72 | 502 / 502 |
| skin | 100% | 2196.22 | 1809 / 1809 | 100% | 9.44 | 472 / 472 |
| stomach | 100% | 1330.59 | 359 / 359 | 100% | 7.31 | 286 / 286 |
| thymus | 100% | 2788.65 | 653 / 653 | 100% | 9.30 | 604 / 605 |
| breast | 100% | 2038.59 | 459 / 459 | 100% | 7.47 | 1116 / 1118 |
| lung | 100% | 1732.39 | 578 / 578 | 100% | 7.36 | 1151 / 1155 |
| intestine | 100% | 1663.69 | 966 / 966 | 100% | 7.75 | 525 / 527 |
| bladder | 100% | 1881.90 | 21 / 21 | 100% | 7.32 | 502 / 504 |
| ovary | 100% | 2265.02 | 180 / 180 | 100% | 6.87 | 428 / 430 |
| pancreas | 100% | 1041.49 | 328 / 328 | 99% | 7.51 | 177 / 178 |
| uterus | 100% | 2188.22 | 170 / 170 | 99% | 7.04 | 456 / 459 |
| adrenal gland | 100% | 1616.21 | 258 / 258 | 99% | 6.79 | 228 / 230 |
| kidney | 100% | 1512.30 | 89 / 89 | 99% | 6.81 | 892 / 901 |
| brain | 99% | 1179.20 | 2626 / 2642 | 100% | 7.68 | 702 / 705 |
| liver | 100% | 835.65 | 225 / 226 | 99% | 5.40 | 402 / 406 |
| adipose | 100% | 1521.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 10.63 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.47 | 29 / 29 |
| spleen | 100% | 1704.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 7.46 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.37 | 1 / 1 |
| blood vessel | 100% | 1492.75 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 994.93 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1038.05 | 842 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 76% | 775.72 | 710 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0051301 | Biological process | cell division |
| GO_0051306 | Biological process | mitotic sister chromatid separation |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0000956 | Biological process | nuclear-transcribed mRNA catabolic process |
| GO_0019827 | Biological process | stem cell population maintenance |
| GO_0006402 | Biological process | mRNA catabolic process |
| GO_0010587 | Biological process | miRNA catabolic process |
| GO_1990074 | Biological process | polyuridylation-dependent mRNA catabolic process |
| GO_0000932 | Cellular component | P-body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000175 | Molecular function | 3'-5'-RNA exonuclease activity |
| GO_0008266 | Molecular function | poly(U) RNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004540 | Molecular function | RNA nuclease activity |
| GO_0000287 | Molecular function | magnesium ion binding |
| Gene name | DIS3L2 |
| Protein name | DIS3 like 3'-5' exoribonuclease 2 DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) |
| Synonyms | FAM6A |
| Description | FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. . |
| Accessions | ENST00000417808.1 Q8IYB7 ENST00000273009.10 [Q8IYB7-3] ENST00000325385.12 [Q8IYB7-1] H7C302 ENST00000418143.1 ENST00000445090.5 [Q8IYB7-4] ENST00000434477.5 ENST00000409401.7 [Q8IYB7-4] ENST00000441279.5 H7C1Q8 C9JGP4 ENST00000433430.5 [Q8IYB7-5] ENST00000390005.9 [Q8IYB7-2] H7C036 |