CRX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0043522Molecular functionleucine zipper domain binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCRX
Protein nameCone-rod homeobox protein
Cone-rod homeobox
SynonymsCORD2
DescriptionFUNCTION: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. .

AccessionsA4GUB7
ENST00000613299.1
H3BUU7
O43186
ENST00000566686.5
ENST00000221996.12
A0A087WTS9