Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 30% ± 13% | |
| smooth muscle cell | 14 studies | 31% ± 12% | |
| pericyte | 14 studies | 30% ± 11% | |
| oligodendrocyte | 13 studies | 39% ± 16% | |
| fibroblast | 12 studies | 28% ± 11% | |
| CD4-positive, alpha-beta T cell | 10 studies | 21% ± 5% | |
| astrocyte | 10 studies | 29% ± 13% | |
| oligodendrocyte precursor cell | 9 studies | 31% ± 14% | |
| adipocyte | 9 studies | 33% ± 8% | |
| glutamatergic neuron | 8 studies | 42% ± 24% | |
| macrophage | 7 studies | 28% ± 10% | |
| regulatory T cell | 7 studies | 20% ± 3% | |
| GABAergic neuron | 7 studies | 42% ± 21% | |
| interneuron | 6 studies | 37% ± 21% | |
| myofibroblast cell | 6 studies | 24% ± 12% | |
| mast cell | 6 studies | 19% ± 3% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 23% ± 4% | |
| neuron | 5 studies | 29% ± 17% | |
| cardiac muscle cell | 5 studies | 30% ± 7% | |
| CD16-positive, CD56-dim natural killer cell, human | 4 studies | 19% ± 2% | |
| granule cell | 4 studies | 26% ± 11% | |
| epithelial cell | 4 studies | 27% ± 14% | |
| dendritic cell | 4 studies | 21% ± 7% | |
| CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
| T cell | 4 studies | 25% ± 4% | |
| endothelial cell of lymphatic vessel | 4 studies | 24% ± 6% | |
| B cell | 3 studies | 21% ± 2% | |
| classical monocyte | 3 studies | 22% ± 3% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 19% ± 3% | |
| GABAergic interneuron | 3 studies | 25% ± 4% | |
| glial cell | 3 studies | 21% ± 5% | |
| microglial cell | 3 studies | 30% ± 13% | |
| myeloid cell | 3 studies | 20% ± 3% | |
| amacrine cell | 3 studies | 22% ± 6% | |
| retinal rod cell | 3 studies | 24% ± 4% | |
| hepatocyte | 3 studies | 35% ± 20% | |
| muscle cell | 3 studies | 24% ± 10% | |
| natural killer cell | 3 studies | 20% ± 1% | |
| alveolar macrophage | 3 studies | 29% ± 10% | |
| monocyte | 3 studies | 26% ± 7% | |
| lymphocyte | 3 studies | 25% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 4818.53 | 245 / 245 | 100% | 13.59 | 502 / 502 |
| thymus | 100% | 5772.20 | 653 / 653 | 100% | 19.37 | 605 / 605 |
| skin | 100% | 3887.67 | 1808 / 1809 | 100% | 20.43 | 472 / 472 |
| esophagus | 100% | 5404.68 | 1444 / 1445 | 100% | 18.71 | 183 / 183 |
| breast | 100% | 5439.80 | 459 / 459 | 100% | 19.38 | 1117 / 1118 |
| uterus | 100% | 6418.69 | 170 / 170 | 100% | 14.38 | 458 / 459 |
| lung | 100% | 5564.99 | 578 / 578 | 100% | 14.86 | 1151 / 1155 |
| bladder | 100% | 6843.95 | 21 / 21 | 100% | 11.77 | 502 / 504 |
| ovary | 100% | 8469.26 | 180 / 180 | 100% | 13.77 | 428 / 430 |
| intestine | 100% | 5175.12 | 966 / 966 | 99% | 13.11 | 524 / 527 |
| kidney | 100% | 2551.60 | 89 / 89 | 99% | 16.14 | 895 / 901 |
| brain | 99% | 2788.96 | 2612 / 2642 | 100% | 19.06 | 705 / 705 |
| adrenal gland | 100% | 3570.75 | 258 / 258 | 97% | 10.39 | 224 / 230 |
| stomach | 98% | 3043.12 | 352 / 359 | 99% | 14.69 | 284 / 286 |
| pancreas | 86% | 1229.54 | 283 / 328 | 99% | 15.43 | 177 / 178 |
| liver | 98% | 1655.65 | 222 / 226 | 82% | 6.11 | 332 / 406 |
| adipose | 100% | 5886.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 9208.15 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 11.63 | 80 / 80 |
| spleen | 100% | 3212.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.36 | 1 / 1 |
| muscle | 99% | 2670.93 | 797 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 2987.32 | 851 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 10.63 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 11.96 | 27 / 29 |
| peripheral blood | 87% | 2238.03 | 805 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097009 | Biological process | energy homeostasis |
| GO_0032793 | Biological process | positive regulation of CREB transcription factor activity |
| GO_0042116 | Biological process | macrophage activation |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0071878 | Biological process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_0050995 | Biological process | negative regulation of lipid catabolic process |
| GO_0016042 | Biological process | lipid catabolic process |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0008140 | Molecular function | cAMP response element binding protein binding |
| Gene name | CRTC3 |
| Protein name | CREB regulated transcription coactivator 3 CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) |
| Synonyms | TORC3 |
| Description | FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). . |
| Accessions | ENST00000687075.1 ENST00000268184.11 [Q6UUV7-1] ENST00000691029.1 [Q6UUV7-1] A0A8I5QJV4 H0YK33 ENST00000558005.1 H0YK64 ENST00000420329.6 [Q6UUV7-3] ENST00000686240.1 ENST00000692149.1 ENST00000560098.5 A0A8I5KTH9 Q6UUV7 |