Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 30% ± 13% | |
smooth muscle cell | 14 studies | 31% ± 12% | |
pericyte | 14 studies | 30% ± 11% | |
oligodendrocyte | 13 studies | 39% ± 16% | |
fibroblast | 12 studies | 28% ± 11% | |
CD4-positive, alpha-beta T cell | 10 studies | 21% ± 5% | |
astrocyte | 10 studies | 29% ± 13% | |
oligodendrocyte precursor cell | 9 studies | 31% ± 14% | |
adipocyte | 9 studies | 33% ± 8% | |
glutamatergic neuron | 8 studies | 42% ± 24% | |
macrophage | 7 studies | 28% ± 10% | |
regulatory T cell | 7 studies | 20% ± 3% | |
GABAergic neuron | 7 studies | 42% ± 21% | |
interneuron | 6 studies | 37% ± 21% | |
myofibroblast cell | 6 studies | 24% ± 12% | |
mast cell | 6 studies | 19% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 23% ± 4% | |
neuron | 5 studies | 29% ± 17% | |
cardiac muscle cell | 5 studies | 30% ± 7% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 19% ± 2% | |
granule cell | 4 studies | 26% ± 11% | |
epithelial cell | 4 studies | 27% ± 14% | |
dendritic cell | 4 studies | 21% ± 7% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
T cell | 4 studies | 25% ± 4% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 6% | |
B cell | 3 studies | 21% ± 2% | |
classical monocyte | 3 studies | 22% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 19% ± 3% | |
GABAergic interneuron | 3 studies | 25% ± 4% | |
glial cell | 3 studies | 21% ± 5% | |
microglial cell | 3 studies | 30% ± 13% | |
myeloid cell | 3 studies | 20% ± 3% | |
amacrine cell | 3 studies | 22% ± 6% | |
retinal rod cell | 3 studies | 24% ± 4% | |
hepatocyte | 3 studies | 35% ± 20% | |
muscle cell | 3 studies | 24% ± 10% | |
natural killer cell | 3 studies | 20% ± 1% | |
alveolar macrophage | 3 studies | 29% ± 10% | |
monocyte | 3 studies | 26% ± 7% | |
lymphocyte | 3 studies | 25% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4818.53 | 245 / 245 | 100% | 13.59 | 502 / 502 |
thymus | 100% | 5772.20 | 653 / 653 | 100% | 19.37 | 605 / 605 |
skin | 100% | 3887.67 | 1808 / 1809 | 100% | 20.43 | 472 / 472 |
esophagus | 100% | 5404.68 | 1444 / 1445 | 100% | 18.71 | 183 / 183 |
breast | 100% | 5439.80 | 459 / 459 | 100% | 19.38 | 1117 / 1118 |
uterus | 100% | 6418.69 | 170 / 170 | 100% | 14.38 | 458 / 459 |
lung | 100% | 5564.99 | 578 / 578 | 100% | 14.86 | 1151 / 1155 |
bladder | 100% | 6843.95 | 21 / 21 | 100% | 11.77 | 502 / 504 |
ovary | 100% | 8469.26 | 180 / 180 | 100% | 13.77 | 428 / 430 |
intestine | 100% | 5175.12 | 966 / 966 | 99% | 13.11 | 524 / 527 |
kidney | 100% | 2551.60 | 89 / 89 | 99% | 16.14 | 895 / 901 |
brain | 99% | 2788.96 | 2612 / 2642 | 100% | 19.06 | 705 / 705 |
adrenal gland | 100% | 3570.75 | 258 / 258 | 97% | 10.39 | 224 / 230 |
stomach | 98% | 3043.12 | 352 / 359 | 99% | 14.69 | 284 / 286 |
pancreas | 86% | 1229.54 | 283 / 328 | 99% | 15.43 | 177 / 178 |
liver | 98% | 1655.65 | 222 / 226 | 82% | 6.11 | 332 / 406 |
adipose | 100% | 5886.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9208.15 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 11.63 | 80 / 80 |
spleen | 100% | 3212.20 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.36 | 1 / 1 |
muscle | 99% | 2670.93 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 2987.32 | 851 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 10.63 | 44 / 45 |
lymph node | 0% | 0 | 0 / 0 | 93% | 11.96 | 27 / 29 |
peripheral blood | 87% | 2238.03 | 805 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097009 | Biological process | energy homeostasis |
GO_0032793 | Biological process | positive regulation of CREB transcription factor activity |
GO_0042116 | Biological process | macrophage activation |
GO_0051289 | Biological process | protein homotetramerization |
GO_0071878 | Biological process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
GO_0050995 | Biological process | negative regulation of lipid catabolic process |
GO_0016042 | Biological process | lipid catabolic process |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0008140 | Molecular function | cAMP response element binding protein binding |
Gene name | CRTC3 |
Protein name | CREB regulated transcription coactivator 3 CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) |
Synonyms | TORC3 |
Description | FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). . |
Accessions | ENST00000687075.1 ENST00000268184.11 [Q6UUV7-1] ENST00000691029.1 [Q6UUV7-1] A0A8I5QJV4 H0YK33 ENST00000558005.1 H0YK64 ENST00000420329.6 [Q6UUV7-3] ENST00000686240.1 ENST00000692149.1 ENST00000560098.5 A0A8I5KTH9 Q6UUV7 |