CRTC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0042116Biological processmacrophage activation
GO_0051289Biological processprotein homotetramerization
GO_0071878Biological processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0016042Biological processlipid catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008140Molecular functioncAMP response element binding protein binding

IV. Literature review

[source]
Gene nameCRTC3
Protein nameCREB regulated transcription coactivator 3
CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)
SynonymsTORC3
DescriptionFUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). .

AccessionsENST00000687075.1
ENST00000268184.11 [Q6UUV7-1]
ENST00000691029.1 [Q6UUV7-1]
A0A8I5QJV4
H0YK33
ENST00000558005.1
H0YK64
ENST00000420329.6 [Q6UUV7-3]
ENST00000686240.1
ENST00000692149.1
ENST00000560098.5
A0A8I5KTH9
Q6UUV7