CNOT9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0007548Biological processsex differentiation
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0017148Biological processnegative regulation of translation
GO_0030015Cellular componentCCR4-NOT core complex
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0000932Cellular componentP-body
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_0019900Molecular functionkinase binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCNOT9
Protein nameCCR4-NOT transcription complex subunit 9
CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog)
CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1)
SynonymsRCD1
RQCD1
DescriptionFUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. .

AccessionsENST00000432877.5
F8WBZ6
ENST00000273064.11 [Q92600-1]
ENST00000627282.2 [Q92600-2]
ENST00000418808.1
H7C0W0
Q92600
ENST00000295701.9 [Q92600-3]
F8WCV7
ENST00000433439.1
D5MQE1