CLK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0005634Cellular componentnucleus
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCLK4
Protein nameCDC like kinase 4
CLK4 protein (cDNA FLJ51841, highly similar to Dual specificity protein kinase CLK4)
dual-specificity kinase (EC 2.7.12.1)
Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)
CDC like kinase 4 (CLK4 protein)
SynonymsDKFZp686A20267
DescriptionFUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. .

AccessionsENST00000522136.5
ENST00000316308.9
Q9HAZ1
E7ES88
E7EWJ6
Q4G0Z5
ENST00000522556.1
Q68D95
B9EG64
Q6P090
ENST00000521621.5
ENST00000520957.1
B7ZL31