Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 6 studies | 29% ± 9% | |
| ionocyte | 5 studies | 75% ± 7% | |
| epithelial cell | 5 studies | 28% ± 8% | |
| club cell | 5 studies | 29% ± 13% | |
| oligodendrocyte | 5 studies | 35% ± 13% | |
| oligodendrocyte precursor cell | 5 studies | 23% ± 8% | |
| respiratory goblet cell | 4 studies | 37% ± 14% | |
| pancreatic ductal cell | 3 studies | 71% ± 18% | |
| intestinal crypt stem cell | 3 studies | 26% ± 10% | |
| glutamatergic neuron | 3 studies | 27% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 34% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 21153.52 | 328 / 328 | 82% | 69.36 | 146 / 178 |
| intestine | 60% | 2370.33 | 580 / 966 | 91% | 54.19 | 478 / 527 |
| lung | 86% | 665.53 | 497 / 578 | 42% | 5.87 | 490 / 1155 |
| prostate | 90% | 551.28 | 221 / 245 | 38% | 3.36 | 189 / 502 |
| stomach | 35% | 61.48 | 125 / 359 | 82% | 42.21 | 234 / 286 |
| liver | 87% | 207.01 | 196 / 226 | 16% | 11.44 | 64 / 406 |
| kidney | 90% | 462.79 | 80 / 89 | 11% | 11.41 | 97 / 901 |
| skin | 68% | 303.42 | 1232 / 1809 | 0% | 0.02 | 2 / 472 |
| esophagus | 24% | 31.55 | 351 / 1445 | 40% | 13.60 | 74 / 183 |
| brain | 46% | 70.07 | 1224 / 2642 | 6% | 0.32 | 44 / 705 |
| uterus | 26% | 49.32 | 45 / 170 | 12% | 2.42 | 54 / 459 |
| ovary | 2% | 2.67 | 4 / 180 | 30% | 4.39 | 131 / 430 |
| bladder | 5% | 60.71 | 1 / 21 | 27% | 15.51 | 138 / 504 |
| adipose | 25% | 54.69 | 304 / 1204 | 0% | 0 | 0 / 0 |
| breast | 11% | 30.97 | 50 / 459 | 2% | 0.23 | 24 / 1118 |
| heart | 7% | 9.27 | 64 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 2% | 3.40 | 21 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.55 | 3 / 653 | 1% | 0.07 | 5 / 605 |
| peripheral blood | 1% | 0.98 | 7 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 0.72 | 5 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0.67 | 1 / 258 | 0% | 0 | 0 / 230 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_1902161 | Biological process | positive regulation of cyclic nucleotide-gated ion channel activity |
| GO_0048240 | Biological process | sperm capacitation |
| GO_1902943 | Biological process | positive regulation of voltage-gated chloride channel activity |
| GO_0050891 | Biological process | multicellular organismal-level water homeostasis |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0060081 | Biological process | membrane hyperpolarization |
| GO_0006904 | Biological process | vesicle docking involved in exocytosis |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_1904322 | Biological process | cellular response to forskolin |
| GO_0070175 | Biological process | positive regulation of enamel mineralization |
| GO_0051454 | Biological process | intracellular pH elevation |
| GO_0015701 | Biological process | bicarbonate transport |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0097186 | Biological process | amelogenesis |
| GO_0045921 | Biological process | positive regulation of exocytosis |
| GO_0030301 | Biological process | cholesterol transport |
| GO_0035377 | Biological process | transepithelial water transport |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0005829 | Cellular component | cytosol |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0030660 | Cellular component | Golgi-associated vesicle membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0140359 | Molecular function | ABC-type transporter activity |
| GO_0043225 | Molecular function | ATPase-coupled inorganic anion transmembrane transporter activity |
| GO_0106138 | Molecular function | Sec61 translocon complex binding |
| GO_0017081 | Molecular function | chloride channel regulator activity |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0015106 | Molecular function | bicarbonate transmembrane transporter activity |
| GO_0015108 | Molecular function | chloride transmembrane transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016853 | Molecular function | isomerase activity |
| GO_0042626 | Molecular function | ATPase-coupled transmembrane transporter activity |
| GO_0019869 | Molecular function | chloride channel inhibitor activity |
| GO_0005260 | Molecular function | intracellularly ATP-gated chloride channel activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0005254 | Molecular function | chloride channel activity |
| Gene name | CFTR |
| Protein name | Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7 (Cystic fibrosis transmembrane conductance regulator/ATP-binding cassette sub-family C member 7) Cystic fibrosis transmembrane conductance regulator CFTR Cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 mutant Cystic fibrosis transmembrane conductance regulating (EC 3.6.3.49) Mutant cystic fibrosis transmembrane conductance regulator (EC 3.6.3.49) Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7 Cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (cAMP-dependent chloride channel) CFTR (Cystic fibrosis transmembrane conductance regulator) Cystic fibrosis transmembrane conductance regulator (EC 3.6.3.49) Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) CF transmembrane conductance regulator |
| Synonyms | ABCC7 |
| Description | FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis . Mediates the transport of chloride ions across the cell membrane . Channel activity is coupled to ATP hydrolysis . The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration . Exerts its function also by modulating the activity of other ion channels and transporters . Plays an important role in airway fluid homeostasis . Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens . Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex . Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G . Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G . May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 . Can inhibit the chloride channel activity of ANO1 . Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation . . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. . |
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