| Name | intracellularly ATP-gated chloride channel activity |
| ID | GO_0005260 |
| collection_id | Molecular function |
| Alternative ID | GO:0005224 |
| Exact synonym | CFTR |
| Description | Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. |
| Related synonym | channel-conductance-controlling ATPase activity |
| Comment | This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator). |
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| Genes |