Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 29% ± 13% | |
| oligodendrocyte precursor cell | 12 studies | 38% ± 17% | |
| astrocyte | 11 studies | 32% ± 15% | |
| microglial cell | 11 studies | 28% ± 10% | |
| GABAergic neuron | 10 studies | 43% ± 24% | |
| glutamatergic neuron | 10 studies | 41% ± 22% | |
| oligodendrocyte | 10 studies | 28% ± 10% | |
| mast cell | 8 studies | 25% ± 8% | |
| macrophage | 7 studies | 31% ± 11% | |
| adipocyte | 7 studies | 25% ± 7% | |
| fibroblast | 7 studies | 30% ± 9% | |
| pericyte | 7 studies | 25% ± 10% | |
| interneuron | 6 studies | 52% ± 26% | |
| retinal cone cell | 6 studies | 38% ± 15% | |
| neuron | 5 studies | 43% ± 18% | |
| epithelial cell | 5 studies | 27% ± 15% | |
| endothelial cell of lymphatic vessel | 5 studies | 29% ± 5% | |
| smooth muscle cell | 5 studies | 20% ± 5% | |
| granule cell | 4 studies | 33% ± 7% | |
| cardiac muscle cell | 4 studies | 28% ± 5% | |
| retinal rod cell | 4 studies | 23% ± 5% | |
| type II pneumocyte | 4 studies | 20% ± 5% | |
| GABAergic interneuron | 3 studies | 41% ± 2% | |
| mesothelial cell | 3 studies | 23% ± 5% | |
| Mueller cell | 3 studies | 20% ± 4% | |
| amacrine cell | 3 studies | 23% ± 8% | |
| glycinergic amacrine cell | 3 studies | 22% ± 4% | |
| hepatocyte | 3 studies | 31% ± 18% | |
| alveolar macrophage | 3 studies | 24% ± 6% | |
| club cell | 3 studies | 21% ± 4% | |
| monocyte | 3 studies | 20% ± 2% | |
| type I pneumocyte | 3 studies | 25% ± 4% | |
| lymphocyte | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1179.85 | 1445 / 1445 | 100% | 21.89 | 183 / 183 |
| intestine | 100% | 2158.26 | 966 / 966 | 100% | 34.29 | 527 / 527 |
| lung | 100% | 909.82 | 578 / 578 | 100% | 17.64 | 1155 / 1155 |
| stomach | 100% | 1082.97 | 359 / 359 | 100% | 31.38 | 286 / 286 |
| bladder | 100% | 1713.48 | 21 / 21 | 100% | 24.91 | 503 / 504 |
| prostate | 100% | 1108.46 | 245 / 245 | 100% | 13.88 | 501 / 502 |
| brain | 100% | 875.01 | 2633 / 2642 | 100% | 19.41 | 705 / 705 |
| uterus | 100% | 1001.33 | 170 / 170 | 100% | 19.91 | 457 / 459 |
| breast | 100% | 735.22 | 459 / 459 | 99% | 16.41 | 1112 / 1118 |
| pancreas | 100% | 801.43 | 328 / 328 | 99% | 16.28 | 177 / 178 |
| ovary | 100% | 683.49 | 180 / 180 | 99% | 12.13 | 427 / 430 |
| thymus | 100% | 725.19 | 652 / 653 | 99% | 11.24 | 600 / 605 |
| kidney | 100% | 769.97 | 89 / 89 | 99% | 10.79 | 888 / 901 |
| liver | 100% | 607.99 | 226 / 226 | 98% | 9.56 | 399 / 406 |
| skin | 100% | 887.45 | 1806 / 1809 | 97% | 15.80 | 459 / 472 |
| adrenal gland | 100% | 935.71 | 258 / 258 | 93% | 12.18 | 215 / 230 |
| adipose | 100% | 787.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.81 | 29 / 29 |
| spleen | 100% | 780.98 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.32 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.02 | 1 / 1 |
| blood vessel | 100% | 916.75 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 656.28 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 676.46 | 855 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 84% | 7.44 | 67 / 80 |
| peripheral blood | 67% | 523.19 | 627 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0090209 | Biological process | negative regulation of triglyceride metabolic process |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005730 | Cellular component | nucleolus |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0016592 | Cellular component | mediator complex |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000307 | Cellular component | cyclin-dependent protein kinase holoenzyme complex |
| GO_1990508 | Cellular component | CKM complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0008353 | Molecular function | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004693 | Molecular function | cyclin-dependent protein serine/threonine kinase activity |
| Gene name | CDK8 |
| Protein name | Cyclin-dependent kinase 8 Cyclin dependent kinase 8 Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) |
| Synonyms | |
| Description | FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. . |
| Accessions | A0A8V8TQY4 ENST00000465820.6 ENST00000536792.5 F5H6D4 A0A0D9SFZ2 Q64FY6 U4PPA3 ENST00000381527.8 [P49336-1] A0A0D9SEP3 ENST00000625988.1 ENST00000700501.1 P49336 |