CDK8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0090209Biological processnegative regulation of triglyceride metabolic process
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_1990508Cellular componentCKM complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK8
Protein nameCyclin-dependent kinase 8
Cyclin dependent kinase 8
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Synonyms
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. .

AccessionsA0A8V8TQY4
ENST00000465820.6
ENST00000536792.5
F5H6D4
A0A0D9SFZ2
Q64FY6
U4PPA3
ENST00000381527.8 [P49336-1]
A0A0D9SEP3
ENST00000625988.1
ENST00000700501.1
P49336