CDK5R1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0048013Biological processephrin receptor signaling pathway
GO_0021766Biological processhippocampus development
GO_0007213Biological processG protein-coupled acetylcholine receptor signaling pathway
GO_0031175Biological processneuron projection development
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0021819Biological processlayer formation in cerebral cortex
GO_0001764Biological processneuron migration
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0007413Biological processaxonal fasciculation
GO_0030182Biological processneuron differentiation
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0021722Biological processsuperior olivary nucleus maturation
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0070315Biological processG1 to G0 transition involved in cell differentiation
GO_0098693Biological processregulation of synaptic vesicle cycle
GO_0021549Biological processcerebellum development
GO_0007420Biological processbrain development
GO_0016241Biological processregulation of macroautophagy
GO_0007158Biological processneuron cell-cell adhesion
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0007411Biological processaxon guidance
GO_0016533Cellular componentprotein kinase 5 complex
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0043292Cellular componentcontractile muscle fiber
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0061575Molecular functioncyclin-dependent protein serine/threonine kinase activator activity
GO_0048487Molecular functionbeta-tubulin binding
GO_0046875Molecular functionephrin receptor binding
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0051015Molecular functionactin filament binding
GO_0004672Molecular functionprotein kinase activity
GO_0002020Molecular functionprotease binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0030295Molecular functionprotein kinase activator activity
GO_0043014Molecular functionalpha-tubulin binding
GO_0016301Molecular functionkinase activity
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDK5R1
Protein nameCyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]
Cyclin dependent kinase 5 regulatory subunit 1
Cyclin-dependent kinase 5 activator
SynonymsNCK5A
CDK5R
DescriptionFUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. .

FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. .

FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. .

AccessionsQ15078
Q8N619
Q8TAM4
ENST00000584792.5
J3QRB5
ENST00000313401.4
ENST00000584716.1