CDK5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK5 at tissue level.

III. Associated gene sets

GO_0045786Biological processnegative regulation of cell cycle
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0021819Biological processlayer formation in cerebral cortex
GO_0051301Biological processcell division
GO_0001764Biological processneuron migration
GO_0043113Biological processreceptor clustering
GO_0070509Biological processcalcium ion import
GO_0051402Biological processneuron apoptotic process
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0045861Biological processnegative regulation of proteolysis
GO_0030334Biological processregulation of cell migration
GO_0045956Biological processpositive regulation of calcium ion-dependent exocytosis
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0001963Biological processsynaptic transmission, dopaminergic
GO_0030517Biological processnegative regulation of axon extension
GO_0006468Biological processprotein phosphorylation
GO_0048511Biological processrhythmic process
GO_0051726Biological processregulation of cell cycle
GO_0019233Biological processsensory perception of pain
GO_0007519Biological processskeletal muscle tissue development
GO_0031175Biological processneuron projection development
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0031914Biological processnegative regulation of synaptic plasticity
GO_0008542Biological processvisual learning
GO_0030182Biological processneuron differentiation
GO_0042981Biological processregulation of apoptotic process
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0021954Biological processcentral nervous system neuron development
GO_0021697Biological processcerebellar cortex formation
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0032801Biological processreceptor catabolic process
GO_0046826Biological processnegative regulation of protein export from nucleus
GO_0021766Biological processhippocampus development
GO_0048813Biological processdendrite morphogenesis
GO_0060079Biological processexcitatory postsynaptic potential
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0007409Biological processaxonogenesis
GO_0007268Biological processchemical synaptic transmission
GO_0022038Biological processcorpus callosum development
GO_0048675Biological processaxon extension
GO_1903421Biological processregulation of synaptic vesicle recycling
GO_0016310Biological processphosphorylation
GO_0007416Biological processsynapse assembly
GO_0035418Biological processprotein localization to synapse
GO_1904646Biological processcellular response to amyloid-beta
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007160Biological processcell-matrix adhesion
GO_0006886Biological processintracellular protein transport
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0048167Biological processregulation of synaptic plasticity
GO_0014044Biological processSchwann cell development
GO_0048709Biological processoligodendrocyte differentiation
GO_0008045Biological processmotor neuron axon guidance
GO_0016241Biological processregulation of macroautophagy
GO_0048148Biological processbehavioral response to cocaine
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0048489Biological processsynaptic vesicle transport
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0016533Cellular componentprotein kinase 5 complex
GO_0098793Cellular componentpresynapse
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0030175Cellular componentfilopodium
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0031594Cellular componentneuromuscular junction
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0030054Cellular componentcell junction
GO_0051879Molecular functionHsp90 protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0005176Molecular functionErbB-2 class receptor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0043125Molecular functionErbB-3 class receptor binding
GO_0030549Molecular functionacetylcholine receptor activator activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity
GO_0008017Molecular functionmicrotubule binding
GO_0016301Molecular functionkinase activity

IV. Literature review

[source]
Gene nameCDK5
Protein nameCell division protein kinase 5
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
SynonymsPSSALRE
CDKN5
hCG_18690
tcag7.772
DescriptionFUNCTION: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. .

AccessionsA0A0S2Z355
A0A090N7W4
Q6IAW3
ENST00000485972.6 [Q00535-1]
ENST00000297518.4 [Q00535-2]
Q00535