CCNT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301Biological processcell division
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0070691Cellular componentP-TEFb complex
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0003677Molecular functionDNA binding
GO_0061575Molecular functioncyclin-dependent protein serine/threonine kinase activator activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0019901Molecular functionprotein kinase binding
GO_0097322Molecular function7SK snRNA binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCNT1
Protein nameCyclin-T1 (CycT1) (Cyclin-T)
Synonyms
DescriptionFUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) . Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II . .; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. .

AccessionsO60563
ENST00000618666.4 [O60563-2]
ENST00000261900.8 [O60563-1]
ENST00000417344.2 [O60563-2]