CARMIL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044351Biological processmacropinocytosis
GO_0046415Biological processurate metabolic process
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0031529Biological processruffle organization
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0030032Biological processlamellipodium assembly
GO_2000813Biological processnegative regulation of barbed-end actin filament capping
GO_0051639Biological processactin filament network formation
GO_1902745Biological processpositive regulation of lamellipodium organization
GO_0051638Biological processbarbed-end actin filament uncapping
GO_0030335Biological processpositive regulation of cell migration
GO_0007015Biological processactin filament organization
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0016477Biological processcell migration
GO_0031941Cellular componentfilamentous actin
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0044354Cellular componentmacropinosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0031252Cellular componentcell leading edge
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0044877Molecular functionprotein-containing complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCARMIL1
Protein nameLRRC16A protein
F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)
Capping protein regulator and myosin 1 linker 1
SynonymsLRRC16
CARMIL
LRRC16A
DescriptionFUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments . Plays a role in lamellipodial protrusion formations and cell migration . .

AccessionsENST00000700669.1
ENST00000635618.1
ENST00000329474.7 [Q5VZK9-1]
A0A0U1RR91
Q5VZK9
A0A8V8TRE2
ENST00000461945.1
A0A0U1RQQ1
B2RTQ5
Q8IW66