CARD11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CARD11 at tissue level.

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0046037Biological processGMP metabolic process
GO_0051260Biological processprotein homooligomerization
GO_0045061Biological processthymic T cell selection
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0045580Biological processregulation of T cell differentiation
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0031295Biological processT cell costimulation
GO_0046710Biological processGDP metabolic process
GO_0048872Biological processhomeostasis of number of cells
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042981Biological processregulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0030890Biological processpositive regulation of B cell proliferation
GO_2000563Biological processpositive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0042100Biological processB cell proliferation
GO_0030183Biological processB cell differentiation
GO_0038202Biological processTORC1 signaling
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0032449Cellular componentCBM complex
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0050700Molecular functionCARD domain binding
GO_0004385Molecular functionguanylate kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCARD11
Protein nameCaspase recruitment domain family member 11
Caspase recruitment domain-containing protein 11
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
SynonymsCARMA1
DescriptionFUNCTION: Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement . Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways . Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation . Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner . Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP . Stimulates the phosphorylation of BCL10 . Also activates the TORC1 signaling pathway . .

AccessionsA0A192GRC6
E2QRC0
Q9BXL7
ENST00000356408.3
H7BY05
A0A192GQG0
ENST00000396946.9
A0A192GQF6
ENST00000355508.3
A0A192GQE0
A0A192GRD0
A0A192GQM1