BDNF report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BDNF at tissue level.

III. Associated gene sets

GO_0031547Biological processbrain-derived neurotrophic factor receptor signaling pathway
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0048668Biological processcollateral sprouting
GO_1900122Biological processpositive regulation of receptor binding
GO_0010976Biological processpositive regulation of neuron projection development
GO_0021675Biological processnerve development
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_2000008Biological processregulation of protein localization to cell surface
GO_0038180Biological processnerve growth factor signaling pathway
GO_0048812Biological processneuron projection morphogenesis
GO_0010832Biological processnegative regulation of myotube differentiation
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0007416Biological processsynapse assembly
GO_0048672Biological processpositive regulation of collateral sprouting
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0051965Biological processpositive regulation of synapse assembly
GO_0031550Biological processpositive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0007411Biological processaxon guidance
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030425Cellular componentdendrite
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0008021Cellular componentsynaptic vesicle
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005163Molecular functionnerve growth factor receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBDNF
Protein nameBrain-derived neurotrophic factor isoform 1
Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]
Brain-derived neurotrophic factor preproprotein isoform 2
Brain derived neurotrophic factor
Brain-derived neurotrophic factor (BDNF)
Brain-derived neurotrophic factor
Synonyms1-5
3-5
2-5
4I-5
4-5
DescriptionFUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 . During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. .; FUNCTION: [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 . Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). .

FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. .

FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. .

FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. .

FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. .

AccessionsP23560
ENST00000356660.9 [P23560-1]
E9PMP3
ENST00000418212.5 [P23560-1]
Q6YNR1
ENST00000530861.5 [P23560-1]
A0A0S2Z3E7
Q96TC2
Q304R1
ENST00000395986.6 [P23560-3]
A0A0S2Z3M9
ENST00000314915.6 [P23560-2]
ENST00000533246.5 [P23560-1]
Q969N8
ENST00000395978.7 [P23560-1]
ENST00000525528.1 [P23560-1]
Q6T2C9
ENST00000439476.6 [P23560-1]
ENST00000533131.5 [P23560-1]
ENST00000532997.5 [P23560-1]
ENST00000530786.5
A0A0E3SU01
ENST00000395981.7 [P23560-1]
ENST00000525950.5 [P23560-1]
ENST00000438929.5 [P23560-4]
ENST00000395983.7 [P23560-1]