Name | Number of supported studies | Average coverage | |
---|---|---|---|
type I pneumocyte | 4 studies | 22% ± 4% | |
glutamatergic neuron | 3 studies | 32% ± 5% |
Insufficient scRNA-seq data for expression of BDNF at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 87% | 103.71 | 567 / 653 | 46% | 1.34 | 280 / 605 |
lung | 91% | 232.97 | 526 / 578 | 26% | 0.80 | 299 / 1155 |
skin | 89% | 204.74 | 1603 / 1809 | 25% | 0.96 | 119 / 472 |
prostate | 93% | 320.58 | 228 / 245 | 21% | 0.36 | 104 / 502 |
bladder | 95% | 278.57 | 20 / 21 | 12% | 0.36 | 59 / 504 |
blood vessel | 94% | 501.27 | 1256 / 1335 | 0% | 0 | 0 / 0 |
brain | 68% | 372.46 | 1806 / 2642 | 26% | 0.92 | 181 / 705 |
ovary | 65% | 105.02 | 117 / 180 | 10% | 0.21 | 45 / 430 |
kidney | 30% | 29.03 | 27 / 89 | 39% | 1.15 | 348 / 901 |
esophagus | 35% | 32.25 | 507 / 1445 | 29% | 0.94 | 53 / 183 |
adrenal gland | 24% | 21.41 | 62 / 258 | 40% | 1.71 | 91 / 230 |
heart | 53% | 211.63 | 457 / 861 | 0% | 0 | 0 / 0 |
uterus | 25% | 32.74 | 43 / 170 | 25% | 1.09 | 117 / 459 |
breast | 40% | 41.74 | 184 / 459 | 8% | 0.32 | 86 / 1118 |
intestine | 38% | 40.40 | 370 / 966 | 6% | 0.15 | 33 / 527 |
adipose | 42% | 58.67 | 503 / 1204 | 0% | 0 | 0 / 0 |
stomach | 26% | 20.04 | 95 / 359 | 8% | 0.16 | 22 / 286 |
muscle | 21% | 37.96 | 165 / 803 | 0% | 0 | 0 / 0 |
pancreas | 1% | 0.69 | 4 / 328 | 16% | 0.31 | 28 / 178 |
tonsil | 0% | 0 | 0 / 0 | 16% | 0.29 | 7 / 45 |
spleen | 12% | 8.68 | 29 / 241 | 0% | 0 | 0 / 0 |
liver | 6% | 4.56 | 14 / 226 | 2% | 0.10 | 9 / 406 |
eye | 0% | 0 | 0 / 0 | 4% | 0.04 | 3 / 80 |
peripheral blood | 1% | 0.80 | 6 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0031547 | Biological process | brain-derived neurotrophic factor receptor signaling pathway |
GO_0050804 | Biological process | modulation of chemical synaptic transmission |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0048668 | Biological process | collateral sprouting |
GO_1900122 | Biological process | positive regulation of receptor binding |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0021675 | Biological process | nerve development |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_2000008 | Biological process | regulation of protein localization to cell surface |
GO_0038180 | Biological process | nerve growth factor signaling pathway |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0010832 | Biological process | negative regulation of myotube differentiation |
GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
GO_0007416 | Biological process | synapse assembly |
GO_0048672 | Biological process | positive regulation of collateral sprouting |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0051965 | Biological process | positive regulation of synapse assembly |
GO_0031550 | Biological process | positive regulation of brain-derived neurotrophic factor receptor signaling pathway |
GO_0007399 | Biological process | nervous system development |
GO_0007411 | Biological process | axon guidance |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0008021 | Cellular component | synaptic vesicle |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005163 | Molecular function | nerve growth factor receptor binding |
GO_0008083 | Molecular function | growth factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | BDNF |
Protein name | Brain-derived neurotrophic factor isoform 1 Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)] Brain-derived neurotrophic factor preproprotein isoform 2 Brain derived neurotrophic factor Brain-derived neurotrophic factor (BDNF) Brain-derived neurotrophic factor |
Synonyms | 1-5 3-5 2-5 4I-5 4-5 |
Description | FUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 . During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. .; FUNCTION: [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 . Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). . FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. . FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. . FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. . FUNCTION: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. . |
Accessions | P23560 ENST00000356660.9 [P23560-1] E9PMP3 ENST00000418212.5 [P23560-1] Q6YNR1 ENST00000530861.5 [P23560-1] A0A0S2Z3E7 Q96TC2 Q304R1 ENST00000395986.6 [P23560-3] A0A0S2Z3M9 ENST00000314915.6 [P23560-2] ENST00000533246.5 [P23560-1] Q969N8 ENST00000395978.7 [P23560-1] ENST00000525528.1 [P23560-1] Q6T2C9 ENST00000439476.6 [P23560-1] ENST00000533131.5 [P23560-1] ENST00000532997.5 [P23560-1] ENST00000530786.5 A0A0E3SU01 ENST00000395981.7 [P23560-1] ENST00000525950.5 [P23560-1] ENST00000438929.5 [P23560-4] ENST00000395983.7 [P23560-1] |