BACE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0016485Biological processprotein processing
GO_0042985Biological processnegative regulation of amyloid precursor protein biosynthetic process
GO_0032438Biological processmelanosome organization
GO_0050435Biological processamyloid-beta metabolic process
GO_0006508Biological processproteolysis
GO_0042593Biological processglucose homeostasis
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0005802Cellular componenttrans-Golgi network
GO_0033162Cellular componentmelanosome membrane
GO_0005768Cellular componentendosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004190Molecular functionaspartic-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBACE2
Protein nameBeta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)
SynonymsUNQ418/PRO852
ASP21
ALP56
AEPLC
CDA13
DescriptionFUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 . Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets . Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells . .

AccessionsENST00000347667.5 [Q9Y5Z0-2]
ENST00000330333.11 [Q9Y5Z0-1]
ENST00000328735.10 [Q9Y5Z0-3]
Q9Y5Z0