Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 35% ± 17% | |
oligodendrocyte | 12 studies | 36% ± 13% | |
endothelial cell | 12 studies | 31% ± 12% | |
microglial cell | 11 studies | 30% ± 13% | |
glutamatergic neuron | 10 studies | 40% ± 24% | |
oligodendrocyte precursor cell | 10 studies | 35% ± 15% | |
fibroblast | 10 studies | 29% ± 13% | |
GABAergic neuron | 9 studies | 44% ± 21% | |
macrophage | 8 studies | 28% ± 13% | |
epithelial cell | 8 studies | 29% ± 13% | |
adipocyte | 7 studies | 32% ± 8% | |
neuron | 6 studies | 37% ± 17% | |
interneuron | 6 studies | 49% ± 23% | |
retinal cone cell | 6 studies | 32% ± 16% | |
kidney loop of Henle epithelial cell | 5 studies | 28% ± 6% | |
retina horizontal cell | 5 studies | 34% ± 15% | |
cardiac muscle cell | 5 studies | 31% ± 8% | |
smooth muscle cell | 5 studies | 23% ± 4% | |
basal cell | 5 studies | 30% ± 15% | |
epithelial cell of proximal tubule | 4 studies | 20% ± 5% | |
granule cell | 4 studies | 30% ± 6% | |
retinal ganglion cell | 4 studies | 31% ± 12% | |
ciliated cell | 4 studies | 21% ± 7% | |
retinal rod cell | 4 studies | 39% ± 10% | |
club cell | 4 studies | 27% ± 9% | |
endothelial cell of lymphatic vessel | 4 studies | 30% ± 8% | |
pericyte | 4 studies | 25% ± 6% | |
type I pneumocyte | 4 studies | 22% ± 8% | |
type II pneumocyte | 4 studies | 21% ± 7% | |
GABAergic interneuron | 3 studies | 37% ± 5% | |
plasma cell | 3 studies | 24% ± 4% | |
GABAergic amacrine cell | 3 studies | 28% ± 14% | |
amacrine cell | 3 studies | 33% ± 21% | |
glycinergic amacrine cell | 3 studies | 30% ± 11% | |
hepatocyte | 3 studies | 48% ± 21% | |
ependymal cell | 3 studies | 33% ± 13% | |
natural killer cell | 3 studies | 22% ± 2% | |
lymphocyte | 3 studies | 27% ± 11% | |
mast cell | 3 studies | 20% ± 3% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 28% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 755.76 | 1445 / 1445 | 100% | 15.28 | 183 / 183 |
intestine | 100% | 1102.03 | 966 / 966 | 100% | 21.77 | 527 / 527 |
prostate | 100% | 1511.37 | 245 / 245 | 100% | 65.47 | 502 / 502 |
stomach | 100% | 1223.03 | 359 / 359 | 100% | 18.91 | 286 / 286 |
kidney | 100% | 2491.84 | 89 / 89 | 100% | 39.94 | 898 / 901 |
brain | 100% | 1156.67 | 2634 / 2642 | 100% | 16.72 | 704 / 705 |
thymus | 100% | 1356.99 | 653 / 653 | 99% | 36.94 | 601 / 605 |
liver | 100% | 824.41 | 226 / 226 | 99% | 20.01 | 403 / 406 |
adrenal gland | 100% | 3077.62 | 258 / 258 | 99% | 32.37 | 228 / 230 |
breast | 100% | 1182.04 | 459 / 459 | 99% | 21.28 | 1108 / 1118 |
pancreas | 100% | 755.44 | 328 / 328 | 99% | 19.23 | 176 / 178 |
lung | 100% | 833.26 | 576 / 578 | 99% | 15.85 | 1146 / 1155 |
ovary | 100% | 976.73 | 180 / 180 | 98% | 16.55 | 423 / 430 |
uterus | 100% | 933.80 | 170 / 170 | 97% | 15.54 | 446 / 459 |
bladder | 100% | 783.43 | 21 / 21 | 96% | 15.45 | 483 / 504 |
skin | 100% | 748.76 | 1807 / 1809 | 88% | 11.51 | 414 / 472 |
adipose | 100% | 1024.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 665.30 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.36 | 1 / 1 |
muscle | 100% | 831.03 | 801 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 722.80 | 1330 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 15.33 | 44 / 45 |
heart | 98% | 1256.58 | 841 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 14.54 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 79% | 12.36 | 63 / 80 |
peripheral blood | 71% | 249.53 | 661 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0006552 | Biological process | L-leucine catabolic process |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0050011 | Molecular function | itaconyl-CoA hydratase activity |
GO_0004490 | Molecular function | methylglutaconyl-CoA hydratase activity |
GO_0004300 | Molecular function | enoyl-CoA hydratase activity |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
Gene name | AUH |
Protein name | Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56) |
Synonyms | |
Description | FUNCTION: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) . Can catalyze the reverse reaction but at a much lower rate in vitro . HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate . Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) . Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro . AREs direct rapid RNA degradation and mRNA deadenylation . Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway . The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite . . |
Accessions | Q13825 ENST00000303617.5 [Q13825-2] ENST00000375731.9 [Q13825-1] |