Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 16 studies | 25% ± 8% | |
classical monocyte | 15 studies | 23% ± 8% | |
glutamatergic neuron | 12 studies | 42% ± 24% | |
endothelial cell | 10 studies | 26% ± 8% | |
GABAergic neuron | 9 studies | 43% ± 23% | |
monocyte | 8 studies | 26% ± 4% | |
epithelial cell | 8 studies | 32% ± 10% | |
astrocyte | 8 studies | 30% ± 14% | |
renal alpha-intercalated cell | 7 studies | 68% ± 14% | |
myeloid cell | 7 studies | 30% ± 12% | |
oligodendrocyte | 7 studies | 28% ± 14% | |
kidney loop of Henle epithelial cell | 6 studies | 24% ± 6% | |
neuron | 6 studies | 32% ± 7% | |
oligodendrocyte precursor cell | 6 studies | 27% ± 10% | |
ionocyte | 5 studies | 69% ± 5% | |
microglial cell | 5 studies | 22% ± 5% | |
retinal ganglion cell | 5 studies | 59% ± 26% | |
retinal cone cell | 5 studies | 28% ± 11% | |
dendritic cell | 5 studies | 27% ± 12% | |
interneuron | 5 studies | 47% ± 25% | |
renal principal cell | 4 studies | 36% ± 13% | |
ciliated cell | 4 studies | 27% ± 10% | |
amacrine cell | 4 studies | 31% ± 11% | |
retina horizontal cell | 4 studies | 32% ± 6% | |
retinal pigment epithelial cell | 4 studies | 34% ± 15% | |
non-classical monocyte | 4 studies | 21% ± 6% | |
type B pancreatic cell | 3 studies | 46% ± 29% | |
conventional dendritic cell | 3 studies | 33% ± 1% | |
hematopoietic precursor cell | 3 studies | 22% ± 3% | |
retinal bipolar neuron | 3 studies | 28% ± 7% | |
GABAergic interneuron | 3 studies | 26% ± 5% | |
abnormal cell | 3 studies | 20% ± 5% | |
mononuclear phagocyte | 3 studies | 24% ± 6% | |
OFF-bipolar cell | 3 studies | 29% ± 14% | |
ON-bipolar cell | 3 studies | 33% ± 17% | |
rod bipolar cell | 3 studies | 28% ± 3% | |
alveolar macrophage | 3 studies | 33% ± 8% | |
basal cell | 3 studies | 24% ± 6% | |
transit amplifying cell | 3 studies | 22% ± 7% | |
granule cell | 3 studies | 27% ± 4% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 35% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2802.13 | 459 / 459 | 100% | 81.62 | 1117 / 1118 |
brain | 100% | 8364.63 | 2634 / 2642 | 100% | 87.13 | 705 / 705 |
lung | 99% | 3664.56 | 575 / 578 | 100% | 67.07 | 1154 / 1155 |
thymus | 100% | 4104.48 | 653 / 653 | 99% | 92.83 | 601 / 605 |
kidney | 100% | 8207.29 | 89 / 89 | 99% | 116.15 | 895 / 901 |
esophagus | 99% | 2683.80 | 1435 / 1445 | 100% | 70.22 | 183 / 183 |
uterus | 99% | 2211.91 | 169 / 170 | 100% | 62.91 | 457 / 459 |
skin | 100% | 4258.21 | 1809 / 1809 | 99% | 84.55 | 467 / 472 |
prostate | 100% | 2380.20 | 244 / 245 | 99% | 63.32 | 498 / 502 |
adrenal gland | 100% | 6842.24 | 258 / 258 | 99% | 65.19 | 227 / 230 |
ovary | 100% | 1859.54 | 180 / 180 | 99% | 37.78 | 424 / 430 |
stomach | 100% | 2352.00 | 359 / 359 | 98% | 44.37 | 281 / 286 |
bladder | 100% | 2197.43 | 21 / 21 | 98% | 50.48 | 495 / 504 |
intestine | 100% | 2433.29 | 964 / 966 | 98% | 42.46 | 517 / 527 |
liver | 100% | 2494.04 | 226 / 226 | 97% | 37.55 | 395 / 406 |
pancreas | 98% | 1816.29 | 321 / 328 | 99% | 47.05 | 176 / 178 |
adipose | 100% | 2907.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 73.83 | 29 / 29 |
spleen | 100% | 4014.61 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 81.57 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.40 | 1 / 1 |
blood vessel | 97% | 1716.02 | 1301 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 48.94 | 77 / 80 |
peripheral blood | 94% | 3937.33 | 869 / 929 | 0% | 0 | 0 / 0 |
heart | 74% | 921.18 | 641 / 861 | 0% | 0 | 0 / 0 |
muscle | 68% | 760.35 | 543 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048388 | Biological process | endosomal lumen acidification |
GO_0015986 | Biological process | proton motive force-driven ATP synthesis |
GO_0007042 | Biological process | lysosomal lumen acidification |
GO_0051452 | Biological process | intracellular pH reduction |
GO_0097401 | Biological process | synaptic vesicle lumen acidification |
GO_0036295 | Biological process | cellular response to increased oxygen levels |
GO_0006879 | Biological process | intracellular iron ion homeostasis |
GO_0007035 | Biological process | vacuolar acidification |
GO_0061795 | Biological process | Golgi lumen acidification |
GO_0016241 | Biological process | regulation of macroautophagy |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0005902 | Cellular component | microvillus |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_1902495 | Cellular component | transmembrane transporter complex |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0033176 | Cellular component | proton-transporting V-type ATPase complex |
GO_0000221 | Cellular component | vacuolar proton-transporting V-type ATPase, V1 domain |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005829 | Cellular component | cytosol |
GO_0098850 | Cellular component | extrinsic component of synaptic vesicle membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0010008 | Cellular component | endosome membrane |
GO_0030141 | Cellular component | secretory granule |
GO_0016469 | Cellular component | proton-transporting two-sector ATPase complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0030665 | Cellular component | clathrin-coated vesicle membrane |
GO_0046961 | Molecular function | proton-transporting ATPase activity, rotational mechanism |
GO_0046933 | Molecular function | proton-transporting ATP synthase activity, rotational mechanism |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP6V1A |
Protein name | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) H(+)-transporting two-sector ATPase (EC 7.1.2.2) ATPase H+ transporting V1 subunit A |
Synonyms | ATP6A1 VPP2 ATP6V1A1 |
Description | FUNCTION: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation . May play a role in neurite development and synaptic connectivity . .; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. . |
Accessions | A0A994J738 ENST00000703904.2 [P38606-1] A0A994J477 ENST00000703911.1 [P38606-1] ENST00000703908.1 ENST00000496747.6 ENST00000475322.1 F8WDJ3 ENST00000703910.1 [P38606-1] ENST00000273398.8 [P38606-1] P38606 ENST00000703909.1 C9JVW8 C9JA17 ENST00000470455.5 ENST00000496747.6 [P38606-2] |