ATP6V1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048388Biological processendosomal lumen acidification
GO_0015986Biological processproton motive force-driven ATP synthesis
GO_0007042Biological processlysosomal lumen acidification
GO_0051452Biological processintracellular pH reduction
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0036295Biological processcellular response to increased oxygen levels
GO_0006879Biological processintracellular iron ion homeostasis
GO_0007035Biological processvacuolar acidification
GO_0061795Biological processGolgi lumen acidification
GO_0016241Biological processregulation of macroautophagy
GO_1902600Biological processproton transmembrane transport
GO_0005902Cellular componentmicrovillus
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_1902495Cellular componenttransmembrane transporter complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0098850Cellular componentextrinsic component of synaptic vesicle membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0030141Cellular componentsecretory granule
GO_0016469Cellular componentproton-transporting two-sector ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0046933Molecular functionproton-transporting ATP synthase activity, rotational mechanism
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP6V1A
Protein nameV-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
H(+)-transporting two-sector ATPase (EC 7.1.2.2)
ATPase H+ transporting V1 subunit A
SynonymsATP6A1
VPP2
ATP6V1A1
DescriptionFUNCTION: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation . May play a role in neurite development and synaptic connectivity . .; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. .

AccessionsA0A994J738
ENST00000703904.2 [P38606-1]
A0A994J477
ENST00000703911.1 [P38606-1]
ENST00000703908.1
ENST00000496747.6
ENST00000475322.1
F8WDJ3
ENST00000703910.1 [P38606-1]
ENST00000273398.8 [P38606-1]
P38606
ENST00000703909.1
C9JVW8
C9JA17
ENST00000470455.5
ENST00000496747.6 [P38606-2]