Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 20 studies | 28% ± 14% | |
astrocyte | 13 studies | 29% ± 11% | |
glutamatergic neuron | 12 studies | 51% ± 23% | |
endothelial cell | 12 studies | 31% ± 13% | |
oligodendrocyte precursor cell | 11 studies | 32% ± 13% | |
oligodendrocyte | 11 studies | 32% ± 11% | |
microglial cell | 10 studies | 33% ± 10% | |
GABAergic neuron | 9 studies | 50% ± 21% | |
myeloid cell | 9 studies | 32% ± 12% | |
monocyte | 8 studies | 24% ± 6% | |
neuron | 8 studies | 41% ± 13% | |
retinal rod cell | 8 studies | 35% ± 9% | |
type II pneumocyte | 7 studies | 21% ± 5% | |
amacrine cell | 7 studies | 35% ± 7% | |
interneuron | 7 studies | 46% ± 24% | |
retinal ganglion cell | 6 studies | 58% ± 19% | |
retinal cone cell | 6 studies | 34% ± 8% | |
fibroblast | 6 studies | 23% ± 10% | |
classical monocyte | 5 studies | 24% ± 9% | |
epithelial cell | 5 studies | 37% ± 12% | |
retina horizontal cell | 5 studies | 30% ± 6% | |
Mueller cell | 5 studies | 21% ± 6% | |
smooth muscle cell | 5 studies | 17% ± 1% | |
retinal bipolar neuron | 4 studies | 31% ± 3% | |
granule cell | 4 studies | 31% ± 7% | |
pancreatic D cell | 3 studies | 28% ± 18% | |
conventional dendritic cell | 3 studies | 24% ± 10% | |
GABAergic interneuron | 3 studies | 41% ± 4% | |
OFF-bipolar cell | 3 studies | 40% ± 3% | |
ON-bipolar cell | 3 studies | 34% ± 6% | |
rod bipolar cell | 3 studies | 28% ± 6% | |
pancreatic A cell | 3 studies | 38% ± 11% | |
abnormal cell | 3 studies | 27% ± 10% | |
ependymal cell | 3 studies | 31% ± 16% | |
enteroendocrine cell | 3 studies | 24% ± 6% | |
alveolar macrophage | 3 studies | 35% ± 8% | |
goblet cell | 3 studies | 27% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 16003.45 | 2642 / 2642 | 100% | 63.53 | 705 / 705 |
intestine | 100% | 5375.22 | 966 / 966 | 100% | 21.01 | 525 / 527 |
prostate | 100% | 5137.55 | 244 / 245 | 100% | 26.51 | 502 / 502 |
thymus | 100% | 6309.83 | 652 / 653 | 100% | 33.39 | 603 / 605 |
esophagus | 100% | 5140.51 | 1445 / 1445 | 99% | 23.17 | 182 / 183 |
skin | 99% | 5711.70 | 1795 / 1809 | 100% | 48.42 | 471 / 472 |
breast | 100% | 4107.12 | 459 / 459 | 98% | 23.45 | 1101 / 1118 |
adrenal gland | 100% | 6033.98 | 258 / 258 | 98% | 56.41 | 226 / 230 |
liver | 99% | 3244.41 | 224 / 226 | 99% | 21.63 | 402 / 406 |
uterus | 100% | 6409.79 | 170 / 170 | 98% | 16.48 | 448 / 459 |
kidney | 100% | 6013.08 | 89 / 89 | 97% | 34.78 | 877 / 901 |
lung | 99% | 5842.06 | 574 / 578 | 98% | 19.67 | 1130 / 1155 |
stomach | 98% | 3486.73 | 351 / 359 | 99% | 21.25 | 283 / 286 |
bladder | 100% | 3858.90 | 21 / 21 | 96% | 15.59 | 483 / 504 |
ovary | 100% | 5522.59 | 180 / 180 | 83% | 10.90 | 358 / 430 |
pancreas | 83% | 1917.55 | 271 / 328 | 98% | 24.83 | 175 / 178 |
eye | 0% | 0 | 0 / 0 | 100% | 68.24 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.33 | 29 / 29 |
muscle | 100% | 8591.76 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 6901.69 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 16.75 | 45 / 45 |
adipose | 100% | 4135.67 | 1200 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4699.91 | 1329 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 3854.08 | 875 / 929 | 0% | 0 | 0 / 0 |
heart | 94% | 3075.92 | 806 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048388 | Biological process | endosomal lumen acidification |
GO_0007042 | Biological process | lysosomal lumen acidification |
GO_0097401 | Biological process | synaptic vesicle lumen acidification |
GO_0007035 | Biological process | vacuolar acidification |
GO_0016241 | Biological process | regulation of macroautophagy |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0030667 | Cellular component | secretory granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0030672 | Cellular component | synaptic vesicle membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0033176 | Cellular component | proton-transporting V-type ATPase complex |
GO_0005829 | Cellular component | cytosol |
GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
GO_0030670 | Cellular component | phagocytic vesicle membrane |
GO_0000220 | Cellular component | vacuolar proton-transporting V-type ATPase, V0 domain |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0042470 | Cellular component | melanosome |
GO_0010008 | Cellular component | endosome membrane |
GO_0016471 | Cellular component | vacuolar proton-transporting V-type ATPase complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0030665 | Cellular component | clathrin-coated vesicle membrane |
GO_0046961 | Molecular function | proton-transporting ATPase activity, rotational mechanism |
GO_0051117 | Molecular function | ATPase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ATP6V0A1 |
Protein name | V-type proton ATPase subunit a V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) |
Synonyms | VPP1 ATP6N1A ATP6N1 |
Description | FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles . In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons . . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. . |
Accessions | ENST00000589759.2 ENST00000703902.1 ENST00000586201.6 ENST00000589213.1 ENST00000587824.5 ENST00000703901.1 [Q93050-2] ENST00000703899.1 A0A994J6N0 A0A994J4L9 ENST00000589727.5 ENST00000588901.6 ENST00000393829.6 [Q93050-1] ENST00000703891.1 ENST00000703890.1 K7ELZ6 ENST00000703888.1 ENST00000588138.2 K7EM24 A0A994J473 A0A994J4L1 ENST00000703889.1 A0A994J728 ENST00000703893.1 A0A994J3Z9 ENST00000703895.1 Q93050 K7ERA6 ENST00000585525.5 ENST00000343619.9 [Q93050-2] K7ERA0 K7EPG4 A0A994J3Z4 ENST00000587510.5 B7Z641 A0A994J731 ENST00000703894.1 A0A994J4L6 ENST00000703900.1 ENST00000703896.1 K7EQW2 K7EN36 ENST00000592324.2 ENST00000703898.1 ENST00000703897.1 A0A994J3Z0 ENST00000537728.5 ENST00000544137.5 A0A994J6N3 ENST00000703903.1 A0A994J403 ENST00000264649.10 [Q93050-3] K7ENA1 A0A994J735 F5H1T6 ENST00000703892.1 B7Z2A9 |