ATP10A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0008360Biological processregulation of cell shape
GO_0045332Biological processphospholipid translocation
GO_1903527Biological processpositive regulation of membrane tubulation
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140345Molecular functionphosphatidylcholine flippase activity
GO_0090554Molecular functionphosphatidylcholine floppase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0140351Molecular functionglycosylceramide flippase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0000287Molecular functionmagnesium ion binding
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity

IV. Literature review

[source]
Gene nameATP10A
Protein namePhospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A)
ATPase phospholipid transporting 10A (putative)
Phospholipid-transporting ATPase (EC 7.6.2.1)
SynonymsATPVC
KIAA0566
ATP10C
ATPVA
DescriptionFUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane . Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking . Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix . Has low flippase activity toward glucosylceramide (GlcCer) . .

AccessionsENST00000555815.7 [O60312-1]
A0A669KBE2
O60312
ENST00000673676.1
ENST00000356865.11 [O60312-1]
ENST00000673679.1
H0YJI4
ENST00000389967.9 [O60312-2]
A0A669KAY1
ENST00000673763.1
A0A669KBH6
ENST00000673747.1
A0A669KB44
A0A669KAW0
ENST00000555756.2
ENST00000673716.1
ENST00000619904.1 [O60312-2]