Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 56% ± 22% | |
smooth muscle cell | 9 studies | 38% ± 11% | |
adipocyte | 6 studies | 35% ± 5% | |
pericyte | 5 studies | 33% ± 14% | |
T cell | 5 studies | 22% ± 4% | |
fibroblast | 5 studies | 20% ± 4% | |
type I pneumocyte | 5 studies | 37% ± 8% | |
mast cell | 4 studies | 23% ± 9% | |
endothelial cell of lymphatic vessel | 3 studies | 27% ± 7% | |
alveolar macrophage | 3 studies | 35% ± 7% | |
natural killer cell | 3 studies | 26% ± 2% | |
type II pneumocyte | 3 studies | 19% ± 2% | |
lymphocyte | 3 studies | 34% ± 11% | |
mesothelial cell | 3 studies | 39% ± 12% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 4 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 93% | 1172.95 | 2463 / 2642 | 97% | 4.57 | 681 / 705 |
breast | 98% | 1624.50 | 450 / 459 | 89% | 3.50 | 997 / 1118 |
skin | 87% | 1111.28 | 1580 / 1809 | 92% | 10.93 | 433 / 472 |
lung | 100% | 2226.09 | 577 / 578 | 73% | 2.98 | 841 / 1155 |
prostate | 84% | 675.19 | 206 / 245 | 87% | 2.30 | 436 / 502 |
kidney | 100% | 1534.55 | 89 / 89 | 60% | 1.86 | 539 / 901 |
thymus | 91% | 810.38 | 597 / 653 | 66% | 1.78 | 401 / 605 |
stomach | 79% | 773.94 | 282 / 359 | 60% | 1.51 | 173 / 286 |
intestine | 92% | 863.76 | 891 / 966 | 42% | 0.99 | 222 / 527 |
esophagus | 80% | 2014.09 | 1150 / 1445 | 53% | 1.25 | 97 / 183 |
adrenal gland | 98% | 2526.92 | 252 / 258 | 24% | 1.24 | 56 / 230 |
bladder | 67% | 642.10 | 14 / 21 | 37% | 1.06 | 186 / 504 |
blood vessel | 100% | 5287.48 | 1334 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 14.25 | 78 / 80 |
adipose | 97% | 1590.02 | 1171 / 1204 | 0% | 0 | 0 / 0 |
ovary | 28% | 251.11 | 51 / 180 | 65% | 2.06 | 279 / 430 |
pancreas | 1% | 8.03 | 4 / 328 | 89% | 3.24 | 159 / 178 |
uterus | 42% | 285.55 | 71 / 170 | 31% | 1.03 | 143 / 459 |
spleen | 60% | 304.52 | 144 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 55% | 1.59 | 16 / 29 |
heart | 43% | 248.93 | 368 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 42% | 0.66 | 19 / 45 |
peripheral blood | 41% | 301.19 | 381 / 929 | 0% | 0 | 0 / 0 |
liver | 2% | 9.98 | 5 / 226 | 18% | 0.57 | 74 / 406 |
muscle | 4% | 21.43 | 34 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0008360 | Biological process | regulation of cell shape |
GO_0045332 | Biological process | phospholipid translocation |
GO_1903527 | Biological process | positive regulation of membrane tubulation |
GO_1990531 | Cellular component | phospholipid-translocating ATPase complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0016020 | Cellular component | membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0140345 | Molecular function | phosphatidylcholine flippase activity |
GO_0090554 | Molecular function | phosphatidylcholine floppase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0140351 | Molecular function | glycosylceramide flippase activity |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0140326 | Molecular function | ATPase-coupled intramembrane lipid transporter activity |
Gene name | ATP10A |
Protein name | Phospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A) ATPase phospholipid transporting 10A (putative) Phospholipid-transporting ATPase (EC 7.6.2.1) |
Synonyms | ATPVC KIAA0566 ATP10C ATPVA |
Description | FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane . Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking . Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix . Has low flippase activity toward glucosylceramide (GlcCer) . . |
Accessions | ENST00000555815.7 [O60312-1] A0A669KBE2 O60312 ENST00000673676.1 ENST00000356865.11 [O60312-1] ENST00000673679.1 H0YJI4 ENST00000389967.9 [O60312-2] A0A669KAY1 ENST00000673763.1 A0A669KBH6 ENST00000673747.1 A0A669KB44 A0A669KAW0 ENST00000555756.2 ENST00000673716.1 ENST00000619904.1 [O60312-2] |