ATG7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0051607Biological processdefense response to virus
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0016236Biological processmacroautophagy
GO_0006501Biological processC-terminal protein lipidation
GO_0009267Biological processcellular response to starvation
GO_0031401Biological processpositive regulation of protein modification process
GO_0042752Biological processregulation of circadian rhythm
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0071455Biological processcellular response to hyperoxia
GO_0000422Biological processautophagy of mitochondrion
GO_0015031Biological processprotein transport
GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0032446Biological processprotein modification by small protein conjugation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048511Biological processrhythmic process
GO_0005576Cellular componentextracellular region
GO_0034774Cellular componentsecretory granule lumen
GO_0005930Cellular componentaxoneme
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0042803Molecular functionprotein homodimerization activity
GO_0019779Molecular functionAtg8 activating enzyme activity
GO_0019778Molecular functionAtg12 activating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG7
Protein nameAutophagy related 7
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
SynonymsAPG7L
DescriptionFUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes . Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). .

AccessionsENST00000427759.5
ENST00000435760.6
ENST00000418682.5
C9JE55
ENST00000354956.9 [O95352-2]
H7C2J8
ENST00000424071.5
H7C059
ENST00000451830.5
ENST00000419112.5
ENST00000685771.1 [O95352-1]
ENST00000354449.7 [O95352-1]
ENST00000444619.5
ENST00000434066.6
H7C369
C9J415
O95352
ENST00000451513.5
H7C2R3
ENST00000423116.1
C9JKA3
ENST00000446450.6 [O95352-3]
C9JGL2
ENST00000693202.1 [O95352-1]
ENST00000446110.1
ENST00000414717.5
H7BZ92
C9JFF4
C9JNU2