Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 34% ± 13% | |
macrophage | 18 studies | 50% ± 26% | |
astrocyte | 17 studies | 45% ± 20% | |
microglial cell | 15 studies | 49% ± 14% | |
oligodendrocyte precursor cell | 12 studies | 34% ± 15% | |
fibroblast | 12 studies | 33% ± 10% | |
oligodendrocyte | 12 studies | 38% ± 13% | |
GABAergic neuron | 10 studies | 47% ± 26% | |
myeloid cell | 10 studies | 48% ± 25% | |
glutamatergic neuron | 9 studies | 58% ± 23% | |
adipocyte | 8 studies | 33% ± 9% | |
endothelial cell of lymphatic vessel | 7 studies | 35% ± 9% | |
pericyte | 7 studies | 26% ± 8% | |
smooth muscle cell | 7 studies | 26% ± 6% | |
interneuron | 6 studies | 45% ± 27% | |
dendritic cell | 6 studies | 37% ± 10% | |
mast cell | 6 studies | 25% ± 11% | |
monocyte | 6 studies | 56% ± 22% | |
neuron | 5 studies | 41% ± 19% | |
cardiac muscle cell | 5 studies | 23% ± 5% | |
T cell | 5 studies | 29% ± 7% | |
type I pneumocyte | 5 studies | 33% ± 7% | |
type II pneumocyte | 5 studies | 30% ± 7% | |
classical monocyte | 4 studies | 21% ± 2% | |
granule cell | 4 studies | 31% ± 13% | |
epithelial cell | 4 studies | 43% ± 20% | |
Mueller cell | 4 studies | 23% ± 3% | |
amacrine cell | 4 studies | 23% ± 3% | |
retina horizontal cell | 4 studies | 21% ± 3% | |
retinal cone cell | 4 studies | 19% ± 4% | |
retinal rod cell | 4 studies | 22% ± 3% | |
B cell | 4 studies | 28% ± 8% | |
ciliated cell | 4 studies | 31% ± 8% | |
club cell | 4 studies | 31% ± 9% | |
natural killer cell | 4 studies | 27% ± 6% | |
GABAergic interneuron | 3 studies | 37% ± 10% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 5% | |
mesothelial cell | 3 studies | 37% ± 9% | |
vein endothelial cell | 3 studies | 36% ± 19% | |
GABAergic amacrine cell | 3 studies | 24% ± 8% | |
glycinergic amacrine cell | 3 studies | 21% ± 2% | |
endothelial cell of vascular tree | 3 studies | 38% ± 16% | |
hepatocyte | 3 studies | 37% ± 17% | |
retinal pigment epithelial cell | 3 studies | 36% ± 20% | |
ependymal cell | 3 studies | 42% ± 20% | |
alveolar macrophage | 3 studies | 73% ± 7% | |
capillary endothelial cell | 3 studies | 23% ± 6% | |
respiratory goblet cell | 3 studies | 35% ± 15% | |
lymphocyte | 3 studies | 34% ± 12% | |
basal cell | 3 studies | 47% ± 19% | |
mucus secreting cell | 3 studies | 31% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1312.39 | 459 / 459 | 100% | 12.18 | 1118 / 1118 |
esophagus | 100% | 1062.62 | 1445 / 1445 | 100% | 7.65 | 183 / 183 |
intestine | 100% | 1050.95 | 966 / 966 | 100% | 9.05 | 527 / 527 |
stomach | 100% | 823.57 | 359 / 359 | 100% | 8.57 | 286 / 286 |
bladder | 100% | 1129.43 | 21 / 21 | 100% | 11.35 | 503 / 504 |
prostate | 100% | 1029.41 | 245 / 245 | 100% | 9.09 | 501 / 502 |
ovary | 100% | 1078.07 | 180 / 180 | 100% | 7.82 | 429 / 430 |
lung | 100% | 1389.93 | 578 / 578 | 100% | 9.42 | 1152 / 1155 |
kidney | 100% | 854.82 | 89 / 89 | 100% | 8.99 | 897 / 901 |
thymus | 100% | 999.89 | 652 / 653 | 100% | 8.88 | 603 / 605 |
pancreas | 99% | 601.76 | 326 / 328 | 100% | 9.95 | 178 / 178 |
uterus | 100% | 1297.69 | 170 / 170 | 99% | 10.29 | 456 / 459 |
skin | 100% | 1871.73 | 1808 / 1809 | 99% | 10.97 | 469 / 472 |
brain | 99% | 926.87 | 2624 / 2642 | 100% | 11.45 | 704 / 705 |
adrenal gland | 100% | 1250.24 | 258 / 258 | 95% | 6.65 | 219 / 230 |
liver | 93% | 413.75 | 210 / 226 | 99% | 5.38 | 401 / 406 |
adipose | 100% | 1334.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 6.93 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.56 | 29 / 29 |
spleen | 100% | 1366.47 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.99 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.84 | 1 / 1 |
blood vessel | 100% | 1294.34 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 1824.90 | 925 / 929 | 0% | 0 | 0 / 0 |
muscle | 100% | 693.98 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 95% | 589.74 | 817 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000045 | Biological process | autophagosome assembly |
GO_0006497 | Biological process | protein lipidation |
GO_0051607 | Biological process | defense response to virus |
GO_0034727 | Biological process | piecemeal microautophagy of the nucleus |
GO_0016236 | Biological process | macroautophagy |
GO_0006501 | Biological process | C-terminal protein lipidation |
GO_0009267 | Biological process | cellular response to starvation |
GO_0031401 | Biological process | positive regulation of protein modification process |
GO_0042752 | Biological process | regulation of circadian rhythm |
GO_0045732 | Biological process | positive regulation of protein catabolic process |
GO_0071455 | Biological process | cellular response to hyperoxia |
GO_0000422 | Biological process | autophagy of mitochondrion |
GO_0015031 | Biological process | protein transport |
GO_0000423 | Biological process | mitophagy |
GO_0006914 | Biological process | autophagy |
GO_0032446 | Biological process | protein modification by small protein conjugation |
GO_0006995 | Biological process | cellular response to nitrogen starvation |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0048511 | Biological process | rhythmic process |
GO_0005576 | Cellular component | extracellular region |
GO_0034774 | Cellular component | secretory granule lumen |
GO_0005930 | Cellular component | axoneme |
GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
GO_0005829 | Cellular component | cytosol |
GO_0000407 | Cellular component | phagophore assembly site |
GO_0005737 | Cellular component | cytoplasm |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0019779 | Molecular function | Atg8 activating enzyme activity |
GO_0019778 | Molecular function | Atg12 activating enzyme activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ATG7 |
Protein name | Autophagy related 7 Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) |
Synonyms | APG7L |
Description | FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes . Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). . |
Accessions | ENST00000427759.5 ENST00000435760.6 ENST00000418682.5 C9JE55 ENST00000354956.9 [O95352-2] H7C2J8 ENST00000424071.5 H7C059 ENST00000451830.5 ENST00000419112.5 ENST00000685771.1 [O95352-1] ENST00000354449.7 [O95352-1] ENST00000444619.5 ENST00000434066.6 H7C369 C9J415 O95352 ENST00000451513.5 H7C2R3 ENST00000423116.1 C9JKA3 ENST00000446450.6 [O95352-3] C9JGL2 ENST00000693202.1 [O95352-1] ENST00000446110.1 ENST00000414717.5 H7BZ92 C9JFF4 C9JNU2 |