ASXL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035360Biological processpositive regulation of peroxisome proliferator activated receptor signaling pathway
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0035517Cellular componentPR-DUB complex
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0003682Molecular functionchromatin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameASXL2
Protein nameASXL transcriptional regulator 2
Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)
SynonymsKIAA1685
ASXH2
DescriptionFUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. .

AccessionsE7EWD6
A0A5F9ZH08
ENST00000673455.1
ENST00000435504.9 [Q76L83-1]
ENST00000404843.5 [Q76L83-2]
Q76L83
ENST00000672666.1
ENST00000336112.9
A0A5F9ZHN2
ENST00000497092.1
A0A5F9ZHC8