ARL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0007224Biological processsmoothened signaling pathway
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0001822Biological processkidney development
GO_0000281Biological processmitotic cytokinesis
GO_0042461Biological processphotoreceptor cell development
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0006893Biological processGolgi to plasma membrane transport
GO_0015031Biological processprotein transport
GO_0042073Biological processintraciliary transport
GO_1903441Biological processprotein localization to ciliary membrane
GO_0005876Cellular componentspindle microtubule
GO_0030496Cellular componentmidbody
GO_0032391Cellular componentphotoreceptor connecting cilium
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005929Cellular componentcilium
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameARL3
Protein nameADP-ribosylation factor-like protein 3
SynonymsARFL3
DescriptionFUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) . Required for normal cytokinesis and cilia signaling . Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E . Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium . Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). .

AccessionsENST00000260746.6
P36405