ARFIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_1905280Biological processnegative regulation of retrograde transport, endosome to Golgi
GO_0050708Biological processregulation of protein secretion
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene nameARFIP1
Protein nameADP-ribosylation factor interacting protein 1 (Arfaptin 1), isoform CRA_b (ARFIP1 protein) (cDNA FLJ53696, highly similar to Arfaptin-1)
Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)
SynonymshCG_26981
DescriptionFUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network . Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold . Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs . In turn, ARFs induce fission . Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells . .

AccessionsENST00000451320.6 [P53367-1]
ENST00000356064.3 [P53367-2]
ENST00000429148.6 [P53367-3]
ENST00000405727.6 [P53367-2]
P53367
ENST00000353617.7 [P53367-1]
B4E273