AQR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0071007Cellular componentU2-type catalytic step 2 spliceosome
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0034458Molecular function3'-5' RNA helicase activity
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAQR
Protein nameAquarius homolog (Mouse), isoform CRA_a (Aquarius intron-binding spliceosomal factor)
Alternative protein AQR
RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)
Aquarius intron-binding spliceosomal factor
SynonymsKIAA0560
hCG_38784
DescriptionFUNCTION: Involved in pre-mRNA splicing as component of the spliceosome . Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis . Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly . May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing . Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) . .

AccessionsH0YH15
ENST00000543879.6
ENST00000156471.10
H0YLN9
ENST00000560117.1
O60306
L8E9N8