AP2A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098884Biological processpostsynaptic neurotransmitter receptor internalization
GO_0006886Biological processintracellular protein transport
GO_0016192Biological processvesicle-mediated transport
GO_0072583Biological processclathrin-dependent endocytosis
GO_0030667Cellular componentsecretory granule membrane
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0030122Cellular componentAP-2 adaptor complex
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0036020Cellular componentendolysosome membrane
GO_0008289Molecular functionlipid binding
GO_0019901Molecular functionprotein kinase binding
GO_0035615Molecular functionclathrin adaptor activity
GO_0003674Molecular functionmolecular_function
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP2A2
Protein nameAP-2 complex subunit alpha-2
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
AP-1 complex subunit gamma
Adaptor related protein complex 2 subunit alpha 2
SynonymsADTAB
HYPJ
CLAPA2
HIP9
KIAA0899
DescriptionFUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 . The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). .

AccessionsENST00000628187.2
ENST00000688963.1
A0A8I5KYZ9
ENST00000524559.2
ENST00000529818.6
A0A0G2JQP3
A0A8I5KY83
ENST00000530801.6
ENST00000528195.6
ENST00000332231.9 [O94973-2]
A0A0G2JS17
ENST00000527024.2
ENST00000626013.2
ENST00000628115.2
ENST00000630212.2
A0A0G2JRF9
ENST00000626787.2
ENST00000627507.2
O94973
ENST00000629128.1
ENST00000693238.1
E9PQP4
ENST00000531548.6
ENST00000534328.6
ENST00000626739.2
A0A0G2JQT9
ENST00000524952.2
A0A0G2JQA4
ENST00000626578.2
ENST00000625871.2
ENST00000627987.2
A0A8I5KV06
A0A0G2JRP9
A0A8I5KPP9
A0A0G2JS82
ENST00000626889.2
A0A0G2JQF7
ENST00000526753.6
A0A0G2JQM1
ENST00000687792.1
E9PNC4
ENST00000629952.2
A0A0G2JRS3
ENST00000691652.1
A0A8I5QJV7
ENST00000627250.2
ENST00000448903.7 [O94973-1]
ENST00000629923.2
ENST00000626798.2
A0A0G2JQV2
ENST00000534485.6
ENST00000627737.2
ENST00000528815.5 [O94973-3]
ENST00000630696.1
ENST00000687890.1
ENST00000629940.2
ENST00000626063.2
E9PPY8