Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 27 studies | 36% ± 18% | |
endothelial cell | 23 studies | 30% ± 14% | |
endothelial cell of lymphatic vessel | 15 studies | 29% ± 11% | |
glutamatergic neuron | 10 studies | 29% ± 18% | |
myeloid cell | 10 studies | 36% ± 16% | |
fibroblast | 8 studies | 23% ± 7% | |
epithelial cell | 7 studies | 34% ± 17% | |
dendritic cell | 7 studies | 22% ± 5% | |
neuron | 6 studies | 30% ± 10% | |
GABAergic neuron | 6 studies | 31% ± 19% | |
interneuron | 5 studies | 37% ± 22% | |
microglial cell | 5 studies | 30% ± 7% | |
retina horizontal cell | 5 studies | 25% ± 6% | |
retinal rod cell | 5 studies | 20% ± 3% | |
monocyte | 5 studies | 21% ± 5% | |
lymphocyte | 5 studies | 21% ± 4% | |
type I pneumocyte | 5 studies | 21% ± 5% | |
astrocyte | 5 studies | 29% ± 10% | |
amacrine cell | 4 studies | 24% ± 9% | |
granule cell | 4 studies | 25% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 27% ± 9% | |
retinal cone cell | 4 studies | 27% ± 7% | |
ciliated cell | 4 studies | 31% ± 15% | |
type II pneumocyte | 4 studies | 24% ± 5% | |
pericyte | 4 studies | 21% ± 5% | |
oligodendrocyte | 4 studies | 23% ± 4% | |
classical monocyte | 3 studies | 21% ± 3% | |
mononuclear phagocyte | 3 studies | 32% ± 11% | |
tissue-resident macrophage | 3 studies | 32% ± 17% | |
alveolar macrophage | 3 studies | 30% ± 8% | |
smooth muscle cell | 3 studies | 19% ± 2% | |
basal cell | 3 studies | 35% ± 16% | |
transit amplifying cell | 3 studies | 34% ± 24% | |
kidney loop of Henle epithelial cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5745.28 | 1445 / 1445 | 100% | 30.06 | 183 / 183 |
intestine | 100% | 6859.98 | 966 / 966 | 100% | 28.95 | 527 / 527 |
liver | 100% | 4475.67 | 226 / 226 | 100% | 23.87 | 406 / 406 |
ovary | 100% | 5524.62 | 180 / 180 | 100% | 22.65 | 430 / 430 |
prostate | 100% | 6378.50 | 245 / 245 | 100% | 38.42 | 502 / 502 |
uterus | 100% | 6769.71 | 170 / 170 | 100% | 26.83 | 459 / 459 |
lung | 100% | 7135.96 | 578 / 578 | 100% | 29.88 | 1154 / 1155 |
kidney | 100% | 8248.19 | 89 / 89 | 100% | 34.64 | 899 / 901 |
brain | 100% | 8666.53 | 2636 / 2642 | 100% | 46.56 | 705 / 705 |
pancreas | 100% | 3904.35 | 327 / 328 | 100% | 30.13 | 178 / 178 |
stomach | 100% | 4518.25 | 359 / 359 | 100% | 29.64 | 285 / 286 |
breast | 100% | 6377.19 | 459 / 459 | 100% | 32.48 | 1114 / 1118 |
thymus | 100% | 5128.95 | 652 / 653 | 100% | 23.48 | 603 / 605 |
skin | 100% | 5637.24 | 1808 / 1809 | 99% | 31.40 | 469 / 472 |
bladder | 100% | 6414.48 | 21 / 21 | 99% | 25.45 | 500 / 504 |
adrenal gland | 100% | 5341.09 | 258 / 258 | 98% | 42.10 | 225 / 230 |
adipose | 100% | 7228.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 34.14 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.94 | 29 / 29 |
spleen | 100% | 17049.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 22.57 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.12 | 1 / 1 |
blood vessel | 100% | 5780.22 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 3445.30 | 855 / 861 | 0% | 0 | 0 / 0 |
muscle | 99% | 2773.66 | 793 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 2615.43 | 871 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0098884 | Biological process | postsynaptic neurotransmitter receptor internalization |
GO_0006886 | Biological process | intracellular protein transport |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_0030667 | Cellular component | secretory granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0030122 | Cellular component | AP-2 adaptor complex |
GO_0030666 | Cellular component | endocytic vesicle membrane |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
GO_0098794 | Cellular component | postsynapse |
GO_0005829 | Cellular component | cytosol |
GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
GO_0036020 | Cellular component | endolysosome membrane |
GO_0008289 | Molecular function | lipid binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0035615 | Molecular function | clathrin adaptor activity |
GO_0003674 | Molecular function | molecular_function |
GO_0097718 | Molecular function | disordered domain specific binding |
GO_0005515 | Molecular function | protein binding |
Gene name | AP2A2 |
Protein name | AP-2 complex subunit alpha-2 AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) AP-1 complex subunit gamma Adaptor related protein complex 2 subunit alpha 2 |
Synonyms | ADTAB HYPJ CLAPA2 HIP9 KIAA0899 |
Description | FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 . The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). . |
Accessions | ENST00000628187.2 ENST00000688963.1 A0A8I5KYZ9 ENST00000524559.2 ENST00000529818.6 A0A0G2JQP3 A0A8I5KY83 ENST00000530801.6 ENST00000528195.6 ENST00000332231.9 [O94973-2] A0A0G2JS17 ENST00000527024.2 ENST00000626013.2 ENST00000628115.2 ENST00000630212.2 A0A0G2JRF9 ENST00000626787.2 ENST00000627507.2 O94973 ENST00000629128.1 ENST00000693238.1 E9PQP4 ENST00000531548.6 ENST00000534328.6 ENST00000626739.2 A0A0G2JQT9 ENST00000524952.2 A0A0G2JQA4 ENST00000626578.2 ENST00000625871.2 ENST00000627987.2 A0A8I5KV06 A0A0G2JRP9 A0A8I5KPP9 A0A0G2JS82 ENST00000626889.2 A0A0G2JQF7 ENST00000526753.6 A0A0G2JQM1 ENST00000687792.1 E9PNC4 ENST00000629952.2 A0A0G2JRS3 ENST00000691652.1 A0A8I5QJV7 ENST00000627250.2 ENST00000448903.7 [O94973-1] ENST00000629923.2 ENST00000626798.2 A0A0G2JQV2 ENST00000534485.6 ENST00000627737.2 ENST00000528815.5 [O94973-3] ENST00000630696.1 ENST00000687890.1 ENST00000629940.2 ENST00000626063.2 E9PPY8 |