ANK2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	19 studies	79% ± 16%	Explore
fibroblast	16 studies	26% ± 8%	Explore
oligodendrocyte	16 studies	83% ± 13%	Explore
oligodendrocyte precursor cell	16 studies	58% ± 20%	Explore
glutamatergic neuron	13 studies	88% ± 13%	Explore
microglial cell	12 studies	42% ± 18%	Explore
GABAergic neuron	11 studies	85% ± 15%	Explore
neuron	9 studies	65% ± 18%	Explore
retinal cone cell	9 studies	74% ± 22%	Explore
retinal rod cell	9 studies	58% ± 23%	Explore
endothelial cell	8 studies	50% ± 20%	Explore
amacrine cell	8 studies	47% ± 13%	Explore
adipocyte	8 studies	26% ± 7%	Explore
smooth muscle cell	8 studies	29% ± 12%	Explore
retina horizontal cell	7 studies	92% ± 7%	Explore
interneuron	7 studies	76% ± 25%	Explore
retinal ganglion cell	7 studies	96% ± 8%	Explore
cardiac muscle cell	6 studies	72% ± 18%	Explore
Mueller cell	6 studies	48% ± 25%	Explore
ionocyte	5 studies	38% ± 17%	Explore
macrophage	5 studies	33% ± 13%	Explore
epithelial cell of proximal tubule	5 studies	33% ± 13%	Explore
retinal bipolar neuron	5 studies	68% ± 8%	Explore
glial cell	5 studies	37% ± 17%	Explore
OFF-bipolar cell	5 studies	71% ± 26%	Explore
ON-bipolar cell	5 studies	73% ± 27%	Explore
pericyte	5 studies	27% ± 8%	Explore
epithelial cell	4 studies	19% ± 3%	Explore
granule cell	4 studies	77% ± 17%	Explore
myofibroblast cell	4 studies	19% ± 2%	Explore
GABAergic interneuron	3 studies	88% ± 8%	Explore
progenitor cell	3 studies	50% ± 27%	Explore
GABAergic amacrine cell	3 studies	73% ± 9%	Explore
glycinergic amacrine cell	3 studies	60% ± 13%	Explore
rod bipolar cell	3 studies	76% ± 11%	Explore
retinal pigment epithelial cell	3 studies	33% ± 13%	Explore
neural progenitor cell	3 studies	53% ± 12%	Explore
ependymal cell	3 studies	77% ± 10%	Explore
connective tissue cell	3 studies	23% ± 6%	Explore
adventitial cell	3 studies	32% ± 7%	Explore
mesothelial cell	3 studies	28% ± 7%	Explore
myeloid cell	3 studies	27% ± 6%	Explore
kidney loop of Henle epithelial cell	3 studies	30% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	72% ± 22%	Explore
eye	10 studies	56% ± 20%	Explore
heart	5 studies	37% ± 14%	Explore
kidney	4 studies	23% ± 5%	Explore
adipose	3 studies	28% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	23728.33	2641 / 2642	100%	50.26	702 / 705
kidney	96%	8356.94	85 / 89	68%	9.08	614 / 901
adrenal gland	75%	3225.47	194 / 258	84%	17.85	193 / 230
skin	39%	1292.68	709 / 1809	92%	13.30	434 / 472
breast	77%	3180.19	353 / 459	47%	2.06	522 / 1118
ovary	95%	4559.56	171 / 180	27%	1.26	114 / 430
thymus	82%	2752.32	537 / 653	28%	1.61	172 / 605
uterus	87%	3199.66	148 / 170	23%	1.78	106 / 459
muscle	99%	6201.24	791 / 803	0%	0	0 / 0
adipose	93%	4983.42	1122 / 1204	0%	0	0 / 0
heart	92%	8580.03	794 / 861	0%	0	0 / 0
intestine	77%	5558.84	748 / 966	11%	0.54	57 / 527
esophagus	64%	3339.71	921 / 1445	24%	1.23	44 / 183
spleen	81%	2875.30	195 / 241	0%	0	0 / 0
prostate	35%	950.91	85 / 245	28%	0.95	143 / 502
eye	0%	0	0 / 0	63%	3.31	50 / 80
blood vessel	62%	2144.28	828 / 1335	0%	0	0 / 0
stomach	33%	1598.40	120 / 359	20%	1.20	56 / 286
bladder	38%	997.05	8 / 21	12%	0.54	59 / 504
lung	24%	685.82	141 / 578	23%	1.29	271 / 1155
pancreas	0%	0	0 / 328	43%	2.82	76 / 178
lymph node	0%	0	0 / 0	38%	1.19	11 / 29
tonsil	0%	0	0 / 0	7%	0.16	3 / 45
liver	0%	0	0 / 226	5%	0.29	21 / 406
peripheral blood	1%	28.94	12 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0098907	Biological process	regulation of SA node cell action potential
GO_0098910	Biological process	regulation of atrial cardiac muscle cell action potential
GO_2001259	Biological process	positive regulation of cation channel activity
GO_0060307	Biological process	regulation of ventricular cardiac muscle cell membrane repolarization
GO_0086015	Biological process	SA node cell action potential
GO_0010882	Biological process	regulation of cardiac muscle contraction by calcium ion signaling
GO_0072659	Biological process	protein localization to plasma membrane
GO_0006897	Biological process	endocytosis
GO_0070296	Biological process	sarcoplasmic reticulum calcium ion transport
GO_0051924	Biological process	regulation of calcium ion transport
GO_0086004	Biological process	regulation of cardiac muscle cell contraction
GO_0086070	Biological process	SA node cell to atrial cardiac muscle cell communication
GO_1901018	Biological process	positive regulation of potassium ion transmembrane transporter activity
GO_0010628	Biological process	positive regulation of gene expression
GO_0086005	Biological process	ventricular cardiac muscle cell action potential
GO_0002027	Biological process	regulation of heart rate
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0007010	Biological process	cytoskeleton organization
GO_0033365	Biological process	protein localization to organelle
GO_0034394	Biological process	protein localization to cell surface
GO_1901021	Biological process	positive regulation of calcium ion transmembrane transporter activity
GO_0036371	Biological process	protein localization to T-tubule
GO_0086014	Biological process	atrial cardiac muscle cell action potential
GO_0070972	Biological process	protein localization to endoplasmic reticulum
GO_0036309	Biological process	protein localization to M-band
GO_0010881	Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_1901019	Biological process	regulation of calcium ion transmembrane transporter activity
GO_0086046	Biological process	membrane depolarization during SA node cell action potential
GO_0003283	Biological process	atrial septum development
GO_0033292	Biological process	T-tubule organization
GO_0050821	Biological process	protein stabilization
GO_0086091	Biological process	regulation of heart rate by cardiac conduction
GO_0043268	Biological process	positive regulation of potassium ion transport
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0086066	Biological process	atrial cardiac muscle cell to AV node cell communication
GO_0051279	Biological process	regulation of release of sequestered calcium ion into cytosol
GO_0015031	Biological process	protein transport
GO_0008104	Biological process	protein localization
GO_0030913	Biological process	paranodal junction assembly
GO_0055117	Biological process	regulation of cardiac muscle contraction
GO_0051597	Biological process	response to methylmercury
GO_0031647	Biological process	regulation of protein stability
GO_0016324	Cellular component	apical plasma membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0043034	Cellular component	costamere
GO_0030018	Cellular component	Z disc
GO_0005739	Cellular component	mitochondrion
GO_0005769	Cellular component	early endosome
GO_0055037	Cellular component	recycling endosome
GO_0005764	Cellular component	lysosome
GO_0042383	Cellular component	sarcolemma
GO_0043005	Cellular component	neuron projection
GO_0030315	Cellular component	T-tubule
GO_0005829	Cellular component	cytosol
GO_0031672	Cellular component	A band
GO_0045211	Cellular component	postsynaptic membrane
GO_0031430	Cellular component	M band
GO_0014704	Cellular component	intercalated disc
GO_0016323	Cellular component	basolateral plasma membrane
GO_0019899	Molecular function	enzyme binding
GO_0030507	Molecular function	spectrin binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0019901	Molecular function	protein kinase binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0051117	Molecular function	ATPase binding
GO_0140031	Molecular function	phosphorylation-dependent protein binding
GO_0008093	Molecular function	cytoskeletal anchor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ANK2
Protein name	Ankyrin 2 Alternative protein ANK2 Ankyrin 2 (cDNA FLJ61595, highly similar to Ankyrin-2) Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
Synonyms	hCG_22680 ANKB
Description	FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate . In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). .
Accessions	A0A5F9ZGY1 A0A5F9ZHN5 ENST00000673048.1 A0A5F9ZH17 ENST00000673109.1 A0A5F9ZH19 ENST00000673363.1 ENST00000672411.1 ENST00000673778.1 ENST00000394537.7 [Q01484-2] ENST00000673555.1 ENST00000672779.1 ENST00000672684.1 A0A5F9ZI46 A0A5F9ZI53 A0A5F9ZI81 ENST00000672990.1 A0A5F9ZHF7 ENST00000671727.1 A0A5F9ZI15 ENST00000671704.1 ENST00000672356.1 I6L894 ENST00000672045.1 ENST00000672251.1 ENST00000673334.1 ENST00000672934.1 ENST00000671762.1 ENST00000672854.1 ENST00000357077.9 [Q01484-4] A0A5F9ZHL9 A0A5F9ZI30 A0A5F9ZHQ5 A0A5F9ZH58 ENST00000505342.6 A0A5F9ZI56 ENST00000672759.1 A0A5K1VW73 A0A5F9ZHQ3 A0A5F9ZGZ1 ENST00000672793.1 ENST00000672315.1 A0A5F9ZH39 A0A5F9ZH18 ENST00000671971.1 A0A5F9ZHY6 ENST00000672088.1 A0A5F9ZHJ6 ENST00000264366.10 A0A5F9ZI08 ENST00000672312.1 A0A5F9ZGY3 ENST00000672240.1 A0A5F9ZH30 ENST00000672362.1 A0A5F9ZGY4 ENST00000673240.1 A0A5F9ZHV4 ENST00000671825.1 ENST00000672366.1 ENST00000673255.1 ENST00000503271.5 H0YAG3 A5XEK0 A0A5F9ZH34 H0Y8X8 ENST00000671756.1 ENST00000672986.1 E9PCH6 E9PHW9 ENST00000634436.1 A0A5F9ZGX8 A0A5F9ZHN0 ENST00000673044.1 A0A087WZU3 ENST00000673353.1 A0A5F9ZI40 ENST00000672930.1 A0A5F9ZH03 ENST00000672830.1 ENST00000672696.1 ENST00000673536.1 ENST00000705785.1 ENST00000672915.1 L8E9V3 A0A5F9ZI73 ENST00000673573.1 A0A5F9ZHM6 ENST00000673298.1 A0A5F9ZHE4 ENST00000673430.1 ENST00000672246.1 A0A5F9ZH35 A0A5F9ZH99 A0A5F9ZHL5 A0A5F9ZI36 ENST00000671882.1 ENST00000672221.1 ENST00000671854.1 ENST00000672502.1 ENST00000671863.1 H0Y8Y2 ENST00000506722.5 [Q01484-5] ENST00000671893.1 ENST00000673453.1 A0A5F9ZHG3 A0A5F9ZH10 ENST00000504454.5 ENST00000671906.1 B7Z651 A0A5F9ZI16 A0A5F9ZHE2 ENST00000673943.1 A0A5F9ZHA1 A0A5F9ZHS1 ENST00000510275.8 A0A5F9ZHC9 ENST00000672090.1 ENST00000672209.1 H0Y931 A0A5F9ZHT8 ENST00000672402.1 A0A5F9ZGS7 ENST00000673546.1 ENST00000671793.1 ENST00000504415.5 ENST00000671951.1 ENST00000514167.1 A0A5F9ZGS5 A0A5F9ZGZ5 ENST00000503423.6 A0A5F9ZI18 A0A669KB19 A0A669KBJ6 ENST00000506344.6 ENST00000672350.1 A0A5F9ZGX3 A0A5F9ZHR8 A0A5F9ZHD2 A0A5F9ZHT4 A0A5F9ZI65 ENST00000673538.1 Q01484 A0A5F9ZHR2 ENST00000672880.1 ENST00000672177.1 A0A5F9ZI69 A0A994J7V8 A0A5F9ZHJ4 A0A0U1RQN6 A0A5F9ZI45 ENST00000672731.1 ENST00000672965.1 ENST00000673231.1 ENST00000612754.2 ENST00000672068.1 A0A5F9ZH38 A0A5F9ZHL3 ENST00000514960.5 A0A5F9ZH70 ENST00000509550.5 ENST00000671809.1 A0A5F9ZI41 H0Y933 A5XEJ9 ENST00000672955.1 D6RHE1

ANK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review