ALDH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	29% ± 14%	Explore
conventional dendritic cell	28 studies	45% ± 16%	Explore
macrophage	26 studies	38% ± 17%	Explore
classical monocyte	24 studies	37% ± 14%	Explore
dendritic cell	22 studies	53% ± 22%	Explore
plasmacytoid dendritic cell	17 studies	34% ± 11%	Explore
monocyte	16 studies	30% ± 10%	Explore
endothelial cell	16 studies	28% ± 11%	Explore
basal cell	16 studies	36% ± 16%	Explore
smooth muscle cell	15 studies	26% ± 9%	Explore
endothelial cell of lymphatic vessel	13 studies	27% ± 11%	Explore
non-classical monocyte	13 studies	23% ± 9%	Explore
myofibroblast cell	13 studies	35% ± 19%	Explore
epithelial cell	12 studies	35% ± 15%	Explore
astrocyte	12 studies	35% ± 13%	Explore
ciliated cell	11 studies	25% ± 10%	Explore
type II pneumocyte	10 studies	38% ± 17%	Explore
pericyte	10 studies	26% ± 8%	Explore
club cell	9 studies	39% ± 15%	Explore
connective tissue cell	9 studies	28% ± 11%	Explore
goblet cell	9 studies	34% ± 11%	Explore
alveolar macrophage	8 studies	66% ± 23%	Explore
type I pneumocyte	8 studies	32% ± 12%	Explore
secretory cell	8 studies	34% ± 14%	Explore
myeloid cell	8 studies	38% ± 12%	Explore
adipocyte	8 studies	32% ± 12%	Explore
respiratory goblet cell	7 studies	36% ± 24%	Explore
enterocyte	7 studies	28% ± 11%	Explore
vein endothelial cell	7 studies	34% ± 19%	Explore
microglial cell	7 studies	27% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	47% ± 11%	Explore
capillary endothelial cell	6 studies	41% ± 13%	Explore
endothelial cell of artery	6 studies	43% ± 20%	Explore
hepatocyte	6 studies	49% ± 22%	Explore
mononuclear phagocyte	5 studies	33% ± 9%	Explore
kidney loop of Henle epithelial cell	5 studies	30% ± 13%	Explore
abnormal cell	5 studies	22% ± 6%	Explore
intestinal crypt stem cell	5 studies	28% ± 9%	Explore
progenitor cell	5 studies	33% ± 16%	Explore
transit amplifying cell	5 studies	30% ± 15%	Explore
brush cell	5 studies	39% ± 10%	Explore
monocyte-derived dendritic cell	4 studies	55% ± 24%	Explore
leukocyte	4 studies	18% ± 4%	Explore
adventitial cell	4 studies	51% ± 12%	Explore
mucus secreting cell	4 studies	30% ± 12%	Explore
Langerhans cell	3 studies	65% ± 14%	Explore
duct epithelial cell	3 studies	29% ± 3%	Explore
hematopoietic precursor cell	3 studies	28% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	34% ± 18%	Explore
renal alpha-intercalated cell	3 studies	21% ± 7%	Explore
retinal bipolar neuron	3 studies	31% ± 15%	Explore
retinal cone cell	3 studies	29% ± 10%	Explore
retinal pigment epithelial cell	3 studies	31% ± 13%	Explore
Mueller cell	3 studies	24% ± 4%	Explore
rod bipolar cell	3 studies	28% ± 9%	Explore
intermediate monocyte	3 studies	41% ± 23%	Explore
inflammatory macrophage	3 studies	26% ± 2%	Explore
endothelial cell of vascular tree	3 studies	24% ± 5%	Explore
GABAergic neuron	3 studies	33% ± 8%	Explore
glutamatergic neuron	3 studies	34% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 7%	Explore
ependymal cell	3 studies	27% ± 12%	Explore
keratinocyte	3 studies	34% ± 14%	Explore
mesothelial cell	3 studies	27% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	32% ± 12%	Explore
intestine	10 studies	23% ± 10%	Explore
kidney	6 studies	25% ± 11%	Explore
eye	6 studies	22% ± 8%	Explore
brain	6 studies	25% ± 5%	Explore
peripheral blood	4 studies	24% ± 9%	Explore
liver	4 studies	30% ± 8%	Explore
uterus	3 studies	25% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	20971.09	2633 / 2642	100%	79.42	705 / 705
liver	100%	62905.69	226 / 226	99%	163.10	403 / 406
stomach	100%	15949.59	359 / 359	98%	57.46	280 / 286
intestine	100%	17158.26	964 / 966	98%	68.13	517 / 527
lung	100%	20189.85	577 / 578	96%	47.09	1104 / 1155
kidney	100%	17372.87	89 / 89	95%	65.14	853 / 901
thymus	98%	8468.48	643 / 653	93%	39.06	564 / 605
adrenal gland	100%	24886.28	258 / 258	91%	37.47	209 / 230
esophagus	100%	16377.47	1444 / 1445	87%	34.11	160 / 183
prostate	100%	9822.73	244 / 245	88%	32.99	440 / 502
uterus	100%	8599.61	170 / 170	85%	32.00	388 / 459
breast	99%	21851.49	454 / 459	81%	27.73	901 / 1118
ovary	100%	10820.22	180 / 180	62%	14.19	266 / 430
bladder	100%	14194.14	21 / 21	60%	30.32	303 / 504
pancreas	54%	2422.98	176 / 328	93%	48.21	165 / 178
skin	86%	13616.49	1563 / 1809	29%	7.22	138 / 472
adipose	100%	28467.58	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	45.39	1 / 1
blood vessel	100%	14612.35	1332 / 1335	0%	0	0 / 0
muscle	100%	12505.77	799 / 803	0%	0	0 / 0
heart	93%	16122.20	799 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	45.25	41 / 45
spleen	84%	4853.02	202 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	35.30	24 / 29
peripheral blood	59%	4147.59	549 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	45%	7.74	36 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0005975	Biological process	carbohydrate metabolic process
GO_1905627	Biological process	regulation of serotonin biosynthetic process
GO_0006068	Biological process	ethanol catabolic process
GO_0006066	Biological process	alcohol metabolic process
GO_0046185	Biological process	aldehyde catabolic process
GO_1903179	Biological process	regulation of dopamine biosynthetic process
GO_0070062	Cellular component	extracellular exosome
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0004030	Molecular function	aldehyde dehydrogenase [NAD(P)+] activity
GO_0051287	Molecular function	NAD binding
GO_0008957	Molecular function	phenylacetaldehyde dehydrogenase (NAD+) activity
GO_0106435	Molecular function	carboxylesterase activity
GO_0004029	Molecular function	aldehyde dehydrogenase (NAD+) activity
GO_0018547	Molecular function	nitroglycerin reductase activity
GO_0043878	Molecular function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	ALDH2
Protein name	Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) Aldehyde dehydrogenase 2 family member
Synonyms	ALDM hCG_2039620
Description	FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. . FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. . FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. . FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. .
Accessions	ENST00000416293.7 [P05091-2] A0A384NPN7 B0LUG2 ENST00000549106.1 ENST00000261733.7 [P05091-1] S4R3S4 F8VSB0 Q9UN17 B0LUG0 ENST00000548536.1 B4YAH7 P05091 B0LUF9

ALDH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review