AK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	26% ± 10%	Explore
fibroblast	18 studies	25% ± 12%	Explore
astrocyte	16 studies	32% ± 16%	Explore
smooth muscle cell	9 studies	23% ± 7%	Explore
endothelial cell of lymphatic vessel	9 studies	21% ± 4%	Explore
pericyte	8 studies	21% ± 5%	Explore
epithelial cell	8 studies	41% ± 12%	Explore
kidney loop of Henle epithelial cell	7 studies	37% ± 6%	Explore
goblet cell	7 studies	25% ± 9%	Explore
connective tissue cell	7 studies	21% ± 4%	Explore
ciliated cell	7 studies	26% ± 10%	Explore
oligodendrocyte	7 studies	29% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	6 studies	33% ± 12%	Explore
interneuron	6 studies	34% ± 15%	Explore
basal cell	6 studies	30% ± 10%	Explore
GABAergic neuron	6 studies	40% ± 16%	Explore
intestinal crypt stem cell	5 studies	23% ± 5%	Explore
transit amplifying cell	5 studies	25% ± 10%	Explore
myofibroblast cell	5 studies	25% ± 5%	Explore
endothelial cell of vascular tree	5 studies	18% ± 4%	Explore
hepatocyte	5 studies	49% ± 19%	Explore
oligodendrocyte precursor cell	5 studies	32% ± 12%	Explore
type I pneumocyte	4 studies	22% ± 6%	Explore
pancreatic A cell	4 studies	33% ± 16%	Explore
progenitor cell	4 studies	18% ± 2%	Explore
neuron	4 studies	33% ± 8%	Explore
renal alpha-intercalated cell	4 studies	29% ± 7%	Explore
brush cell	4 studies	25% ± 7%	Explore
club cell	4 studies	22% ± 4%	Explore
glutamatergic neuron	4 studies	43% ± 10%	Explore
hematopoietic precursor cell	3 studies	23% ± 7%	Explore
type B pancreatic cell	3 studies	38% ± 19%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 4%	Explore
endothelial cell of artery	3 studies	18% ± 1%	Explore
glial cell	3 studies	24% ± 8%	Explore
placental villous trophoblast	3 studies	23% ± 7%	Explore
pro-B cell	3 studies	26% ± 1%	Explore
lymphocyte	3 studies	19% ± 2%	Explore
pancreatic ductal cell	3 studies	45% ± 20%	Explore
abnormal cell	3 studies	31% ± 15%	Explore
ependymal cell	3 studies	44% ± 12%	Explore
enteroendocrine cell	3 studies	28% ± 9%	Explore
respiratory goblet cell	3 studies	20% ± 5%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 1%	Explore
erythroblast	3 studies	34% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	21% ± 5%	Explore
renal principal cell	3 studies	22% ± 4%	Explore
secretory cell	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	29% ± 11%	Explore
lung	5 studies	23% ± 6%	Explore
liver	5 studies	32% ± 14%	Explore
intestine	4 studies	21% ± 6%	Explore
kidney	4 studies	24% ± 5%	Explore
pancreas	3 studies	40% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5346.65	1445 / 1445	100%	59.95	183 / 183
pancreas	100%	2613.12	328 / 328	100%	45.54	178 / 178
prostate	100%	5212.65	245 / 245	100%	70.18	502 / 502
stomach	100%	4679.24	359 / 359	100%	66.83	286 / 286
lung	100%	4192.35	577 / 578	100%	50.14	1155 / 1155
intestine	100%	5658.65	966 / 966	100%	70.06	526 / 527
bladder	100%	5035.76	21 / 21	100%	60.60	503 / 504
brain	100%	3980.54	2640 / 2642	100%	66.41	704 / 705
uterus	100%	4907.30	170 / 170	100%	56.66	458 / 459
liver	100%	6843.61	226 / 226	100%	71.20	405 / 406
breast	100%	5434.52	459 / 459	100%	47.65	1115 / 1118
ovary	100%	5992.23	180 / 180	100%	51.52	428 / 430
thymus	100%	5386.19	653 / 653	100%	69.56	602 / 605
kidney	100%	6916.80	89 / 89	99%	49.83	896 / 901
adrenal gland	100%	6869.02	258 / 258	99%	55.94	227 / 230
skin	100%	4984.09	1809 / 1809	93%	38.95	440 / 472
adipose	100%	5808.96	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.18	29 / 29
muscle	100%	10888.32	803 / 803	0%	0	0 / 0
spleen	100%	3276.13	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.55	45 / 45
ureter	0%	0	0 / 0	100%	28.59	1 / 1
blood vessel	100%	4427.03	1334 / 1335	0%	0	0 / 0
heart	97%	6220.26	833 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	32.92	75 / 80
peripheral blood	37%	1161.81	344 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046039	Biological process	GTP metabolic process
GO_0009142	Biological process	nucleoside triphosphate biosynthetic process
GO_0046033	Biological process	AMP metabolic process
GO_0046051	Biological process	UTP metabolic process
GO_0046041	Biological process	ITP metabolic process
GO_0006172	Biological process	ADP biosynthetic process
GO_0007596	Biological process	blood coagulation
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0004017	Molecular function	adenylate kinase activity
GO_0005525	Molecular function	GTP binding
GO_0046899	Molecular function	nucleoside triphosphate adenylate kinase activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	AK3
Protein name	GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)
Synonyms	AK3L1 AK6 AKL3L
Description	FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. . FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. . FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. .
Accessions	Q7Z531 ENST00000381809.8 [Q9UIJ7-1] ENST00000359883.6 [Q9UIJ7-2] Q9UIJ7 ENST00000447596.4 [Q9UIJ7-3] Q7Z4Y4 ENST00000611749.4 [Q9UIJ7-2]

AK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review