AGTPBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007628Biological processadult walking behavior
GO_0001754Biological processeye photoreceptor cell differentiation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0035609Biological processC-terminal protein deglutamylation
GO_0021702Biological processcerebellar Purkinje cell differentiation
GO_0060041Biological processretina development in camera-type eye
GO_0050905Biological processneuromuscular process
GO_0035610Biological processprotein side chain deglutamylation
GO_0021772Biological processolfactory bulb development
GO_0098957Biological processanterograde axonal transport of mitochondrion
GO_0007005Biological processmitochondrion organization
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0098958Biological processretrograde axonal transport of mitochondrion
GO_0006508Biological processproteolysis
GO_0021954Biological processcentral nervous system neuron development
GO_0035608Biological processprotein deglutamylation
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_0015631Molecular functiontubulin binding
GO_0004181Molecular functionmetallocarboxypeptidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameAGTPBP1
Protein nameCytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1)
Cytosolic carboxypeptidase 1 (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Protein deglutamylase CCP1)
SynonymsKIAA1035
NNA1
CCP1
DescriptionFUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins . Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin . Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate . Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK . Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis . .

AccessionsENST00000357081.8 [Q9UPW5-1]
J3KNS1
ENST00000337006.8
ENST00000376083.7 [Q9UPW5-2]
ENST00000628899.1 [Q9UPW5-3]
Q9UPW5