Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 13 studies | 53% ± 22% | |
oligodendrocyte precursor cell | 10 studies | 27% ± 12% | |
GABAergic neuron | 8 studies | 44% ± 21% | |
retinal cone cell | 8 studies | 55% ± 15% | |
retinal rod cell | 8 studies | 36% ± 20% | |
interneuron | 6 studies | 43% ± 17% | |
retinal ganglion cell | 6 studies | 43% ± 18% | |
neuron | 5 studies | 30% ± 7% | |
amacrine cell | 4 studies | 35% ± 15% | |
granule cell | 4 studies | 32% ± 4% | |
astrocyte | 4 studies | 26% ± 12% | |
endothelial cell | 3 studies | 46% ± 20% | |
GABAergic interneuron | 3 studies | 43% ± 18% | |
glycinergic amacrine cell | 3 studies | 24% ± 7% | |
rod bipolar cell | 3 studies | 33% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 98% | 9963.53 | 2587 / 2642 | 86% | 14.07 | 607 / 705 |
thymus | 94% | 1201.95 | 615 / 653 | 56% | 3.39 | 340 / 605 |
prostate | 70% | 730.73 | 172 / 245 | 74% | 5.44 | 370 / 502 |
breast | 74% | 821.05 | 340 / 459 | 69% | 16.10 | 772 / 1118 |
liver | 100% | 5971.53 | 226 / 226 | 30% | 3.12 | 122 / 406 |
kidney | 81% | 637.17 | 72 / 89 | 30% | 2.15 | 273 / 901 |
adrenal gland | 43% | 334.51 | 112 / 258 | 61% | 8.07 | 140 / 230 |
pancreas | 70% | 622.62 | 228 / 328 | 22% | 2.57 | 40 / 178 |
adipose | 85% | 864.79 | 1018 / 1204 | 0% | 0 | 0 / 0 |
uterus | 57% | 632.86 | 97 / 170 | 27% | 1.62 | 124 / 459 |
skin | 4% | 22.12 | 67 / 1809 | 78% | 16.05 | 369 / 472 |
heart | 77% | 649.92 | 660 / 861 | 0% | 0 | 0 / 0 |
muscle | 69% | 636.68 | 551 / 803 | 0% | 0 | 0 / 0 |
spleen | 67% | 1033.02 | 161 / 241 | 0% | 0 | 0 / 0 |
bladder | 33% | 183.05 | 7 / 21 | 21% | 1.06 | 108 / 504 |
ovary | 36% | 300.48 | 64 / 180 | 14% | 0.67 | 60 / 430 |
blood vessel | 48% | 540.06 | 641 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 44% | 4.99 | 35 / 80 |
stomach | 25% | 148.71 | 91 / 359 | 15% | 1.54 | 43 / 286 |
lung | 20% | 118.17 | 113 / 578 | 18% | 0.89 | 206 / 1155 |
esophagus | 17% | 105.03 | 247 / 1445 | 17% | 0.77 | 31 / 183 |
intestine | 4% | 28.93 | 42 / 966 | 11% | 0.66 | 60 / 527 |
tonsil | 0% | 0 | 0 / 0 | 13% | 0.52 | 6 / 45 |
lymph node | 0% | 0 | 0 / 0 | 10% | 2.91 | 3 / 29 |
peripheral blood | 4% | 38.31 | 36 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032793 | Biological process | positive regulation of CREB transcription factor activity |
GO_0006171 | Biological process | cAMP biosynthetic process |
GO_0007616 | Biological process | long-term memory |
GO_0019933 | Biological process | cAMP-mediated signaling |
GO_0042752 | Biological process | regulation of circadian rhythm |
GO_0007623 | Biological process | circadian rhythm |
GO_0071277 | Biological process | cellular response to calcium ion |
GO_0007409 | Biological process | axonogenesis |
GO_1904322 | Biological process | cellular response to forskolin |
GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
GO_1900273 | Biological process | positive regulation of long-term synaptic potentiation |
GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0150076 | Biological process | neuroinflammatory response |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0098839 | Cellular component | postsynaptic density membrane |
GO_0098793 | Cellular component | presynapse |
GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0070062 | Cellular component | extracellular exosome |
GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0008294 | Molecular function | calcium- and calmodulin-responsive adenylate cyclase activity |
GO_0004016 | Molecular function | adenylate cyclase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005516 | Molecular function | calmodulin binding |
Gene name | ADCY1 |
Protein name | Adenylate cyclase type I (EC 4.6.1.1) Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) adenylate cyclase (EC 4.6.1.1) Alternative protein ADCY1 |
Synonyms | hCG_19245 |
Description | FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). . |
Accessions | Q08828 C9J1J0 ENST00000432715.5 Q8NFM5 L0R809 ENST00000297323.12 ENST00000621543.1 |