Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 14 studies | 21% ± 6% | |
endothelial cell | 13 studies | 24% ± 7% | |
epithelial cell | 8 studies | 31% ± 13% | |
ciliated cell | 8 studies | 27% ± 11% | |
epithelial cell of proximal tubule | 6 studies | 41% ± 11% | |
plasmacytoid dendritic cell | 6 studies | 23% ± 7% | |
memory B cell | 6 studies | 18% ± 2% | |
kidney loop of Henle epithelial cell | 5 studies | 28% ± 6% | |
natural killer cell | 5 studies | 21% ± 4% | |
fibroblast | 5 studies | 22% ± 5% | |
cardiac muscle cell | 5 studies | 22% ± 3% | |
hepatocyte | 5 studies | 40% ± 17% | |
GABAergic neuron | 5 studies | 37% ± 16% | |
astrocyte | 5 studies | 31% ± 9% | |
glutamatergic neuron | 5 studies | 48% ± 23% | |
oligodendrocyte precursor cell | 5 studies | 27% ± 9% | |
oligodendrocyte | 5 studies | 24% ± 5% | |
hematopoietic precursor cell | 4 studies | 23% ± 6% | |
plasma cell | 4 studies | 26% ± 13% | |
plasmablast | 4 studies | 41% ± 16% | |
renal alpha-intercalated cell | 4 studies | 41% ± 6% | |
myeloid cell | 4 studies | 19% ± 5% | |
precursor B cell | 4 studies | 26% ± 7% | |
retinal cone cell | 4 studies | 28% ± 9% | |
macrophage | 4 studies | 21% ± 3% | |
adipocyte | 4 studies | 24% ± 4% | |
interneuron | 4 studies | 36% ± 20% | |
microglial cell | 3 studies | 21% ± 3% | |
smooth muscle cell | 3 studies | 16% ± 1% | |
enterocyte | 3 studies | 18% ± 2% | |
pro-B cell | 3 studies | 30% ± 6% | |
rod bipolar cell | 3 studies | 22% ± 1% | |
germinal center B cell | 3 studies | 25% ± 2% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 5% | |
abnormal cell | 3 studies | 32% ± 3% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 32% ± 19% | |
enteroendocrine cell | 3 studies | 24% ± 8% | |
intestinal crypt stem cell | 3 studies | 21% ± 1% | |
basal cell | 3 studies | 33% ± 7% | |
transit amplifying cell | 3 studies | 23% ± 7% | |
neuron | 3 studies | 36% ± 8% | |
hematopoietic stem cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 2649.28 | 180 / 180 | 100% | 29.94 | 429 / 430 |
brain | 100% | 2867.56 | 2634 / 2642 | 100% | 40.44 | 705 / 705 |
esophagus | 100% | 3386.59 | 1443 / 1445 | 99% | 25.90 | 181 / 183 |
thymus | 100% | 2509.76 | 651 / 653 | 99% | 31.28 | 599 / 605 |
breast | 100% | 2821.13 | 459 / 459 | 98% | 39.63 | 1101 / 1118 |
liver | 100% | 6784.85 | 226 / 226 | 98% | 56.72 | 396 / 406 |
prostate | 100% | 1822.14 | 244 / 245 | 98% | 33.14 | 491 / 502 |
kidney | 100% | 6460.57 | 89 / 89 | 97% | 52.74 | 876 / 901 |
uterus | 99% | 2037.66 | 169 / 170 | 97% | 32.32 | 445 / 459 |
bladder | 100% | 2355.90 | 21 / 21 | 96% | 28.21 | 485 / 504 |
pancreas | 98% | 1844.22 | 322 / 328 | 98% | 23.25 | 174 / 178 |
intestine | 100% | 3189.95 | 966 / 966 | 95% | 26.29 | 502 / 527 |
stomach | 100% | 2635.35 | 358 / 359 | 95% | 24.83 | 273 / 286 |
lung | 94% | 1693.55 | 546 / 578 | 100% | 29.42 | 1150 / 1155 |
adrenal gland | 100% | 6273.73 | 258 / 258 | 92% | 27.01 | 212 / 230 |
skin | 96% | 1723.53 | 1731 / 1809 | 94% | 32.86 | 443 / 472 |
muscle | 100% | 11173.89 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2473.26 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.85 | 1 / 1 |
adipose | 100% | 2816.44 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2609.63 | 1331 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 27.60 | 44 / 45 |
heart | 97% | 7956.06 | 839 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 54.42 | 28 / 29 |
eye | 0% | 0 | 0 / 0 | 69% | 15.13 | 55 / 80 |
peripheral blood | 31% | 2967.56 | 287 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009791 | Biological process | post-embryonic development |
GO_0005978 | Biological process | glycogen biosynthetic process |
GO_0051793 | Biological process | medium-chain fatty acid catabolic process |
GO_0055007 | Biological process | cardiac muscle cell differentiation |
GO_0001889 | Biological process | liver development |
GO_0006111 | Biological process | regulation of gluconeogenesis |
GO_0042594 | Biological process | response to starvation |
GO_0019254 | Biological process | carnitine metabolic process, CoA-linked |
GO_0045329 | Biological process | carnitine biosynthetic process |
GO_0051791 | Biological process | medium-chain fatty acid metabolic process |
GO_0009409 | Biological process | response to cold |
GO_0033539 | Biological process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0005739 | Cellular component | mitochondrion |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005634 | Cellular component | nucleus |
GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
GO_0070991 | Molecular function | medium-chain fatty acyl-CoA dehydrogenase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0003995 | Molecular function | acyl-CoA dehydrogenase activity |
Gene name | ACADM |
Protein name | Acyl-CoA dehydrogenase medium chain Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH) Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7) Acyl-CoA dehydrogenase C-4 to C-12 straight chain isoform 3 (Acyl-CoA dehydrogenase medium chain) |
Synonyms | hCG_22915 |
Description | FUNCTION: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats . The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA . Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) . Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains . . |
Accessions | ENST00000526129.5 ENST00000681430.1 ENST00000679530.1 E9PQA8 A0A7P0T8G6 ENST00000680749.1 ENST00000680964.1 ENST00000420607.6 [P11310-2] H0YDT5 A0A7P0T932 A0A7P0TB51 A0A7P0TAB2 A0A7P0TBD1 ENST00000680517.1 ENST00000680948.1 E9PJM9 E9PLN7 Q5T4U5 A0A7P0TA63 ENST00000541113.6 ENST00000526196.5 ENST00000679704.1 P11310 ENST00000681916.1 ENST00000680844.1 ENST00000681063.1 ENST00000680694.1 A0A7P0TA39 ENST00000532509.5 ENST00000681616.1 E9PIX8 F6YB23 E9PRX4 ENST00000681446.1 A0A7P0T8B6 ENST00000681450.1 ENST00000680691.1 ENST00000681209.1 ENST00000370841.9 [P11310-1] ENST00000680613.1 A0A7P0TB55 A0A0S2Z3A5 ENST00000534334.5 ENST00000680662.1 ENST00000679687.1 A0A7P0TBF2 ENST00000680798.1 ENST00000681720.1 ENST00000528016.1 A0A7P0Z4Q0 ENST00000679976.1 ENST00000681037.1 ENST00000681790.1 A0A7P0TB28 A0A7P0T9W7 ENST00000680805.1 ENST00000681621.1 ENST00000681548.1 A0A0S2Z366 ENST00000370834.9 A0A7P0T8J9 ENST00000525808.5 ENST00000680743.1 A0A7P0TAZ5 ENST00000681361.1 ENST00000530953.6 ENST00000679709.1 |