ACAA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902109Biological processnegative regulation of mitochondrial membrane permeability involved in apoptotic process
GO_0006635Biological processfatty acid beta-oxidation
GO_0006695Biological processcholesterol biosynthetic process
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0071456Biological processcellular response to hypoxia
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0003985Molecular functionacetyl-CoA C-acetyltransferase activity
GO_0003988Molecular functionacetyl-CoA C-acyltransferase activity
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0003986Molecular functionacetyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameACAA2
Protein nameAcetyl-CoA acyltransferase 2
3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)
Synonyms
DescriptionFUNCTION: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs . Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage . .

AccessionsENST00000285093.15
K7EJB1
P42765
ENST00000586100.1
K7ER88
ENST00000587994.5
K7EME0
ENST00000589432.5
A0A0B4J2A4
ENST00000586485.5
ENST00000585948.5
K7EJ68