Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 23 studies | 23% ± 7% | |
pericyte | 23 studies | 27% ± 8% | |
endothelial cell | 21 studies | 33% ± 14% | |
astrocyte | 17 studies | 39% ± 15% | |
ciliated cell | 16 studies | 31% ± 11% | |
smooth muscle cell | 14 studies | 22% ± 6% | |
oligodendrocyte precursor cell | 14 studies | 35% ± 15% | |
glutamatergic neuron | 12 studies | 60% ± 24% | |
oligodendrocyte | 11 studies | 31% ± 9% | |
GABAergic neuron | 10 studies | 50% ± 23% | |
neuron | 9 studies | 41% ± 18% | |
type I pneumocyte | 8 studies | 27% ± 7% | |
myofibroblast cell | 8 studies | 23% ± 6% | |
connective tissue cell | 8 studies | 26% ± 7% | |
amacrine cell | 8 studies | 31% ± 7% | |
epithelial cell | 7 studies | 37% ± 18% | |
interneuron | 7 studies | 52% ± 21% | |
microglial cell | 7 studies | 27% ± 8% | |
macrophage | 6 studies | 30% ± 5% | |
retina horizontal cell | 6 studies | 35% ± 7% | |
Mueller cell | 6 studies | 29% ± 7% | |
basal cell | 6 studies | 28% ± 19% | |
retinal bipolar neuron | 5 studies | 29% ± 3% | |
retinal ganglion cell | 5 studies | 34% ± 12% | |
retinal cone cell | 5 studies | 25% ± 6% | |
retinal rod cell | 5 studies | 24% ± 6% | |
cardiac muscle cell | 5 studies | 26% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 23% ± 3% | |
club cell | 5 studies | 23% ± 6% | |
plasmacytoid dendritic cell | 5 studies | 22% ± 7% | |
abnormal cell | 4 studies | 35% ± 12% | |
granule cell | 4 studies | 36% ± 13% | |
retinal pigment epithelial cell | 4 studies | 31% ± 20% | |
myeloid cell | 4 studies | 20% ± 3% | |
dendritic cell | 4 studies | 21% ± 3% | |
progenitor cell | 3 studies | 24% ± 4% | |
T cell | 3 studies | 19% ± 1% | |
endothelial cell of artery | 3 studies | 16% ± 1% | |
neural crest cell | 3 studies | 26% ± 3% | |
GABAergic interneuron | 3 studies | 45% ± 1% | |
capillary endothelial cell | 3 studies | 18% ± 4% | |
GABAergic amacrine cell | 3 studies | 34% ± 6% | |
OFF-bipolar cell | 3 studies | 29% ± 5% | |
ON-bipolar cell | 3 studies | 30% ± 4% | |
glycinergic amacrine cell | 3 studies | 29% ± 2% | |
rod bipolar cell | 3 studies | 32% ± 7% | |
neural progenitor cell | 3 studies | 37% ± 5% | |
ependymal cell | 3 studies | 44% ± 13% | |
type II pneumocyte | 3 studies | 18% ± 2% | |
goblet cell | 3 studies | 26% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 10505.90 | 2641 / 2642 | 100% | 32.32 | 704 / 705 |
prostate | 100% | 4554.09 | 245 / 245 | 100% | 10.17 | 501 / 502 |
ovary | 100% | 5500.03 | 180 / 180 | 100% | 9.71 | 428 / 430 |
thymus | 100% | 5544.02 | 653 / 653 | 100% | 14.59 | 602 / 605 |
breast | 100% | 3672.11 | 459 / 459 | 99% | 10.02 | 1110 / 1118 |
lung | 100% | 4113.33 | 576 / 578 | 98% | 6.68 | 1134 / 1155 |
bladder | 100% | 4358.43 | 21 / 21 | 96% | 5.54 | 486 / 504 |
kidney | 100% | 3764.70 | 89 / 89 | 95% | 8.24 | 859 / 901 |
skin | 99% | 2742.01 | 1792 / 1809 | 96% | 10.34 | 454 / 472 |
uterus | 100% | 5764.02 | 170 / 170 | 95% | 7.35 | 436 / 459 |
esophagus | 99% | 3445.30 | 1426 / 1445 | 96% | 6.84 | 176 / 183 |
adrenal gland | 100% | 2918.95 | 258 / 258 | 95% | 9.60 | 218 / 230 |
intestine | 99% | 4278.70 | 957 / 966 | 93% | 4.85 | 490 / 527 |
stomach | 95% | 2435.39 | 341 / 359 | 94% | 5.39 | 270 / 286 |
pancreas | 70% | 983.75 | 231 / 328 | 98% | 7.25 | 175 / 178 |
liver | 76% | 1075.43 | 172 / 226 | 48% | 2.37 | 196 / 406 |
spleen | 100% | 2987.41 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4409.21 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 2869.77 | 1200 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 3719.67 | 837 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 5.04 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 86% | 2.93 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 83% | 3.97 | 66 / 80 |
muscle | 71% | 946.52 | 574 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 23% | 844.17 | 214 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010592 | Biological process | positive regulation of lamellipodium assembly |
GO_0001764 | Biological process | neuron migration |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0008154 | Biological process | actin polymerization or depolymerization |
GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
GO_0061001 | Biological process | regulation of dendritic spine morphogenesis |
GO_0070309 | Biological process | lens fiber cell morphogenesis |
GO_0016601 | Biological process | Rac protein signal transduction |
GO_2000601 | Biological process | positive regulation of Arp2/3 complex-mediated actin nucleation |
GO_0000423 | Biological process | mitophagy |
GO_0016477 | Biological process | cell migration |
GO_0098858 | Cellular component | actin-based cell projection |
GO_0005856 | Cellular component | cytoskeleton |
GO_0043197 | Cellular component | dendritic spine |
GO_0032433 | Cellular component | filopodium tip |
GO_0005829 | Cellular component | cytosol |
GO_0005912 | Cellular component | adherens junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0030027 | Cellular component | lamellipodium |
GO_0031209 | Cellular component | SCAR complex |
GO_0005634 | Cellular component | nucleus |
GO_0070064 | Molecular function | proline-rich region binding |
GO_0019900 | Molecular function | kinase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0035591 | Molecular function | signaling adaptor activity |
GO_0008093 | Molecular function | cytoskeletal anchor activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | ABI2 |
Protein name | Abl interactor 2 Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) |
Synonyms | ARGBPIA |
Description | FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation . Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge . Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells . . |
Accessions | ENST00000444584.1 A0A7D9NKC8 F8WAL6 F8WAU3 ENST00000422511.6 E7EUA1 Q9NYB9 F8WEB9 ENST00000451591.6 E9PEZ7 A0A0A0MQU9 E7EP65 ENST00000416001.5 H0Y6B5 ENST00000295851.10 ENST00000413635.5 F8WCD7 ENST00000424558.5 ENST00000447762.5 A0A0C4DG21 F8WBL5 F8WAQ3 ENST00000261018.12 ENST00000417864.5 H7C3Q7 ENST00000430418.5 ENST00000261017.9 [Q9NYB9-2] ENST00000431886.5 ENST00000425253.1 ENST00000454023.1 E7EW77 ENST00000441061.5 ENST00000261016.11 F8WAZ8 |