ABI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0001764Biological processneuron migration
GO_0007010Biological processcytoskeleton organization
GO_0008154Biological processactin polymerization or depolymerization
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0070309Biological processlens fiber cell morphogenesis
GO_0016601Biological processRac protein signal transduction
GO_2000601Biological processpositive regulation of Arp2/3 complex-mediated actin nucleation
GO_0000423Biological processmitophagy
GO_0016477Biological processcell migration
GO_0098858Cellular componentactin-based cell projection
GO_0005856Cellular componentcytoskeleton
GO_0043197Cellular componentdendritic spine
GO_0032433Cellular componentfilopodium tip
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0031209Cellular componentSCAR complex
GO_0005634Cellular componentnucleus
GO_0070064Molecular functionproline-rich region binding
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0031267Molecular functionsmall GTPase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameABI2
Protein nameAbl interactor 2
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
SynonymsARGBPIA
DescriptionFUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation . Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge . Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells . .

AccessionsENST00000444584.1
A0A7D9NKC8
F8WAL6
F8WAU3
ENST00000422511.6
E7EUA1
Q9NYB9
F8WEB9
ENST00000451591.6
E9PEZ7
A0A0A0MQU9
E7EP65
ENST00000416001.5
H0Y6B5
ENST00000295851.10
ENST00000413635.5
F8WCD7
ENST00000424558.5
ENST00000447762.5
A0A0C4DG21
F8WBL5
F8WAQ3
ENST00000261018.12
ENST00000417864.5
H7C3Q7
ENST00000430418.5
ENST00000261017.9 [Q9NYB9-2]
ENST00000431886.5
ENST00000425253.1
ENST00000454023.1
E7EW77
ENST00000441061.5
ENST00000261016.11
F8WAZ8