ABCE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000054Biological processribosomal subunit export from nucleus
GO_0006413Biological processtranslational initiation
GO_0072344Biological processrescue of stalled ribosome
GO_0032790Biological processribosome disassembly
GO_0006417Biological processregulation of translation
GO_0060702Biological processnegative regulation of endoribonuclease activity
GO_0006415Biological processtranslational termination
GO_0022626Cellular componentcytosolic ribosome
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0060698Molecular functionendoribonuclease inhibitor activity
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity
GO_0043273Molecular functionCTPase activity
GO_0043024Molecular functionribosomal small subunit binding
GO_0005506Molecular functioniron ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameABCE1
Protein nameATP binding cassette subfamily E member 1
ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)
SynonymsRNASEL1
OK/SW-cl.40
RNASELI
RLI
RNS4I
DescriptionFUNCTION: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly . Able to hydrolyze ATP, GTP, UTP and CTP . Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits . Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) . Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway . Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy . RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL . Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway . .; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. .; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. .

AccessionsENST00000296577.9
H0Y990
D6R9I9
ENST00000507193.5
D6RGF4
P61221
ENST00000504292.1
ENST00000502586.5