ZNRF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070936Biological processprotein K48-linked ubiquitination
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0061909Biological processautophagosome-lysosome fusion
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005764Cellular componentlysosome
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNRF1
Protein nameE3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Alternative protein ZNRF1
SynonymsNIN283
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation . Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation . Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery . Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production . Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response . .

AccessionsENST00000320619.10 [Q8ND25-2]
ENST00000566250.5
H3BRB6
ENST00000567962.5 [Q8ND25-1]
H3BUF0
L8E9D1
ENST00000335325.9 [Q8ND25-1]
J3KTB9
ENST00000568351.1
Q8ND25
ENST00000568511.1