Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 25% ± 11% | |
mast cell | 15 studies | 28% ± 13% | |
glutamatergic neuron | 7 studies | 43% ± 25% | |
oligodendrocyte precursor cell | 7 studies | 24% ± 8% | |
GABAergic neuron | 7 studies | 37% ± 20% | |
interneuron | 6 studies | 36% ± 18% | |
neuron | 5 studies | 44% ± 10% | |
epithelial cell | 5 studies | 39% ± 14% | |
ciliated cell | 5 studies | 24% ± 5% | |
astrocyte | 5 studies | 28% ± 8% | |
squamous epithelial cell | 4 studies | 41% ± 20% | |
basal cell | 4 studies | 32% ± 12% | |
club cell | 4 studies | 23% ± 6% | |
retinal ganglion cell | 4 studies | 19% ± 3% | |
cardiac muscle cell | 4 studies | 25% ± 3% | |
regulatory T cell | 4 studies | 23% ± 6% | |
oligodendrocyte | 4 studies | 23% ± 5% | |
hematopoietic precursor cell | 3 studies | 35% ± 13% | |
capillary endothelial cell | 3 studies | 27% ± 8% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 26% ± 3% | |
endothelial cell of lymphatic vessel | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2304.71 | 1445 / 1445 | 100% | 10.81 | 183 / 183 |
ovary | 100% | 1288.92 | 180 / 180 | 100% | 13.03 | 430 / 430 |
stomach | 100% | 1292.08 | 359 / 359 | 100% | 8.89 | 286 / 286 |
thymus | 100% | 2368.13 | 653 / 653 | 100% | 18.92 | 605 / 605 |
uterus | 100% | 1568.62 | 170 / 170 | 100% | 12.72 | 459 / 459 |
intestine | 100% | 1702.64 | 966 / 966 | 100% | 8.98 | 526 / 527 |
liver | 100% | 1031.95 | 226 / 226 | 100% | 6.62 | 405 / 406 |
lung | 100% | 1744.46 | 577 / 578 | 100% | 10.77 | 1154 / 1155 |
brain | 99% | 1401.26 | 2628 / 2642 | 100% | 9.02 | 705 / 705 |
bladder | 100% | 1520.71 | 21 / 21 | 99% | 12.31 | 500 / 504 |
adrenal gland | 100% | 1221.67 | 258 / 258 | 99% | 12.81 | 228 / 230 |
breast | 100% | 1352.51 | 459 / 459 | 99% | 8.99 | 1108 / 1118 |
skin | 100% | 1491.87 | 1808 / 1809 | 98% | 6.06 | 464 / 472 |
prostate | 100% | 1096.76 | 245 / 245 | 98% | 4.67 | 490 / 502 |
kidney | 100% | 1000.69 | 89 / 89 | 97% | 4.70 | 872 / 901 |
pancreas | 94% | 555.75 | 309 / 328 | 99% | 9.44 | 177 / 178 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.68 | 1 / 1 |
adipose | 100% | 1320.77 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2346.52 | 801 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 818.97 | 1322 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 906.15 | 849 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 3.49 | 71 / 80 |
lymph node | 0% | 0 | 0 / 0 | 86% | 9.83 | 25 / 29 |
spleen | 70% | 275.49 | 168 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 57% | 405.39 | 525 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0034145 | Biological process | positive regulation of toll-like receptor 4 signaling pathway |
GO_0061909 | Biological process | autophagosome-lysosome fusion |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005764 | Cellular component | lysosome |
GO_0030672 | Cellular component | synaptic vesicle membrane |
GO_0005768 | Cellular component | endosome |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | ZNRF1 |
Protein name | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) RING-type E3 ubiquitin transferase (EC 2.3.2.27) Alternative protein ZNRF1 |
Synonyms | NIN283 |
Description | FUNCTION: E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation . Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation . Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery . Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production . Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response . . |
Accessions | ENST00000320619.10 [Q8ND25-2] ENST00000566250.5 H3BRB6 ENST00000567962.5 [Q8ND25-1] H3BUF0 L8E9D1 ENST00000335325.9 [Q8ND25-1] J3KTB9 ENST00000568351.1 Q8ND25 ENST00000568511.1 |